A. Diuretic drugs Furosemide速尿 1. Pharmacological effects (1) Diuretic effects nhibiting the Na*-k+-2Cl cotransporter( symport) of the luminal membrane in the thick portion of the ascending limb of the loop of Henle and reducing the reabsorption of Nat, K+ and cl- Most efficacious among the diuretic drugs, because the ascending limb accounts for the reabsorption of 25-30% of filtered Nacl and downstream sies are not able to compensate for this increased nat load
Furosemide 速尿 1. Pharmacological effects (1) Diuretic effects Inhibiting the Na+-K+-2Cl- cotransporter （symport) of the luminal membrane in the thick portion of the ascending limb of the loop of Henle, and reducing the reabsorption of Na+ , K+ and Cl- . Most efficacious among the diuretic drugs, because the ascending limb accounts for the reabsorption of 25-30% of filtered NaCl and downstream sies are not able to compensate for this increased Na+ load. A. Diuretic drugs
THICK ASCENDING LIMB umen Interstitial Na+4(+2c Space symport inhibitors A△△ Nat K+ Na (3 Nat K (+)凵L() 70mV sd mV CI Ca 32+ Mg 2+ 10 mV
A. Diuretic drugs Blocking kidney' s ability to concentrate urine during hydropenia by decreasing the hypertonic medullary interstitium Impairing kidney s ability to excrete a dilute urine Also, increasing excretion of Ca 2+, Mg2+ by abolition of transepithelial potential difference
Blocking kidney’s ability to concentrate urine during hydropenia, by decreasing the hypertonic medullary interstitium. Impairing kidney’s ability to excrete a dilute urine. Also, increasing excretion of Ca2+, Mg2+ by abolition of transepithelial potential difference. A. Diuretic drugs