BIOCHEMISTRYANDMOLECULARBIOLOGYChapter 21Amino acids:disposal of nitrogenDepartmentof Biochemistry and Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Chapter 21 Amino acids: disposal of nitrogen
BIOCHEMISTRYANDMOLECULARBIOLOGY1.overviewAmino acids contain nitrogen, carbon, hydrogenand oxygenatoms.Removal of the a-amino groups by transaminationand oxidative deamination, forming ammonia andthe a- ketoacids.Department of Biochemistry and Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢Amino acids contain nitrogen, carbon, hydrogen and oxygen atoms. ➢ Removal of the α-amino groups by transamination and oxidative deamination, forming ammonia and the α- ketoacids. 1. overview
BIOCHEMISTRYANDMOLECULARBIOLOGYtransaminationRR.RR2转氨酶CO=0H-C-NH+H-CNH+AminotransferaseCOOHCOOHCOOHCOOHoxidativedeaminationNHNH,Glutamate服外基医已HO可基疾大内本dehydrogenaseCH-COOHL谷氨酸脱氢酶、C-COOHC-COOH+NH城，基摩-HO2轻婚基度特的（CH）-COOHNADNADH+HH+（CH）2-COOH(CH）-COOH饿丙公谷氨酸glutamateα-酮成二酸a-ketoglutarateDepartment of BiochemistryandMolecularBiology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Aminotransferase Glutamate dehydrogenase glutamate α-ketoglutarate transamination oxidative deamination
BIOCHEMISTRYANDMOLECULARBIOLOGY1.overviewa- ketoacids are converted to common intermediatesof energy producing metabolic pathways Some specialized products that are derived fromamino acids.Department of Biochemistry and Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢α- ketoacids are converted to common intermediates of energy producing metabolic pathways. ➢ Some specialized products that are derived from amino acids. 1. overview
出BIOCHEMISTRYANDMOLECULARBIOLOGY1.overview A portion of the free ammonia is excreted in the urine.Most ammonia is used in the synthesis of urea.Department ofBiochemistryandMolecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢ A portion of the free ammonia is excreted in the urine. ➢ Most ammonia is used in the synthesis of urea. 1. overview