BIOCHEMISTRYANDMOLECULARBIOLOGYChapter31Structure and FunctionofRNADepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Chapter 31 Structure and Function of RNA
BIOCHEMISTRYANDMOLECULARBIOLOGYOutline*overview* The Structure and Function of Messenger RNA*The Structure and function of tRNA* The Structure and function of ribosome RNA*Synthesis ofRNADepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Outline *overview * The Structure and Function of Messenger RNA *The Structure and function of tRNA * The Structure and function of ribosome RNA *Synthesis of RNA
ABIOCHEMISTRYANDMOLECULARBIOLOGY1.overviewClassification, distribution and function of RNAFunctionMitochondrionNucleus and cytosolrRNArRNAmt rRNAComponentof ribosomeTemplateforproteinmRNAmRNAmt mRNAsynthesisTransfer aminotRNAtRNAmt tRNAacidHeterogeneousnuclear RNAPremature of mRNAHnRNASmall nuclearSnRNARNASplicingand transfertohnRNASmall nucleolarSnoRNAModify rRNARNAComponentof proteinSmall cytoplasmicSCRNA/7SL-RNAlocalization signalRNArecognitionsysteminEReSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Classification, distribution and function of RNA 1. overview
BIOCHEMISTRYANDMOLECULARBIOLOGY2.The StructureandFunctionofMessengerRNACharacteristic of structure mRNA:1. 5' Capping is in the most of eukaryote the cap is a 7-methyl guanosine- m7GpppNm-2.Most eukaryotic mRNA have a chain of 40 to 200adenine nucleotides attached to the 3'-endDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 2. The Structure and Function of Messenger RNA * Characteristic of structure mRNA: 1. 5’ Capping is in the most of eukaryote the cap is a 7- methyl guanosine- m7GpppNm- . 2. Most eukaryotic mRNA have a chain of 40 to 200 adenine nucleotides attached to the 3’-end
BIOCHEMISTRYANDMOLECULARBIOLOGYThe Structure of Cap5'cap3'polyAAUGGUGG.GCGAGGTGTATIGA.3'untranslation5'untranslationCoding regionregionregionDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY The Structure of Cap 5’cap 3’polyA 5’ untranslation region 3’untranslation region Coding region