BIOCHEMISTRYANDMOLECULARBIOLOGYChapter 18phospholipid metabolismDepartment of Biochemistryand MolecularBiology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Chapter 18 phospholipid metabolism
BIOCHEMISTRYANDMOLECULARBIOLOGYOutline*Structure of phospholipid*Synthesis of phospholipids*Function of phospholipids*Degradation of phospholipidsDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Outline *Structure of phospholipid *Synthesis of phospholipids *Function of phospholipids *Degradation of phospholipids
BIOCHEMISTRYANDMOLECULARBIOLOGY1.Structure of phospholipidThere are two classes of phospholipids:those that have glycerol as a backbone and those thatcontain sphingosineDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY There are two classes of phospholipids: those that have glycerol as a backbone and those that contain sphingosine. 1. Structure of phospholipid
ABIOCHEMISTRYANDMOLECULARBIOLOGY00CH2-0-C-R11IR2-C-0-CHOCH2-0-P-0-XOHThe structure of phospholipids that have glycerolbackboneDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY The structure of phospholipids that have glycerol backbone
BIOCHEMISTRYANDMOLECULARBIOLOGY2.SynthesisofphospholipidsThese synthetic pathways involve the phosphorylationof choline or ethanolamine, followed by conversion tothe activated form, CDP-choline or CDP-ethanolamine. Finally, choline-phosphate or ethanolamine-phosphate is transferred from the nucleotide (leavingCMP) to a molecule of diacylglycerol Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 2. Synthesis of phospholipids These synthetic pathways involve the phosphorylation of choline or ethanolamine, followed by conversion to the activated form, CDP-choline or CDP-ethanolamine. Finally, choline-phosphate or ethanolaminephosphate is transferred from the nucleotide (leaving CMP) to a molecule of diacylglycerol