ABIOCHEMISTRYANDMOLECULARBIOLOGYRequirementMasterthecontentMolecular cloningFamiliarwith the content1.Genetic disease2. Molecular hybridization3.Polymerasechainreaction4.Restriction fragment length polymorphism(RFLP)Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Requirement Master the content Familiar with the content 1.Genetic disease 2. Molecular hybridization 3. Polymerase chain reaction 4.Restriction fragment length polymorphism(RFLP) Molecular cloning
BIOCHEMISTRYANDMOLECULARBIOLOGYChapter 28MolecularBasis ofInherited DiseaseDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Chapter 28 Molecular Basis of Inherited Disease
BIOCHEMISTRYANDMOLECULARBIOLOGYOutline*Overview*Genetic disease*Molecular cloning* Polymerase chain reaction*Molecularhybridization* Restriction fragment length polymorphism(RFLP)Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Outline *Overview *Genetic disease *Molecular cloning * Polymerase chain reaction * Molecular hybridization * Restriction fragment length polymorphism(RFLP）
BIOCHEMISTRYANDMOLECULARBIOLOGY1.overview>Genetic diseases are disorders in which theclinical symptoms are linked to alterations in DNA The human genome contains DNA withapproximately 3 billion(109) base pairs that encode30,000 to 40,000 genes located on 23 pairs ofchromosomes.Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢Genetic diseases are disorders in which the clinical symptoms are linked to alterations in DNA ➢ The human genome contains DNA with approximately 3 billion(109) base pairs that encode 30,000 to 40,000 genes located on 23 pairs of chromosomes. 1. overview
BIOCHEMISTRYANDMOLECULARBIOLOGY1.overview>It is now to determine the nucleotide sequence oflong stretches of DNA, and it is expected that theentire seguence of the human genome called thehuman genome project.Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢It is now to determine the nucleotide sequence of long stretches of DNA, and it is expected that the entire sequence of the human genome called the human genome project. 1. overview