BIOCHEMISTRYANDMOLECULARBIOLOGYChapter 14Metabolism ofmonosaccharides anddisaccharidesDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Metabolism of monosaccharides and disaccharides Chapter 14
山BIOCHEMISTRYANDMOLECULARBIOLOGYOverviewGlucose is the most commonmonosaccharideconsumed by humans, and its metabolism hasbeen discussed extensivelyDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Glucose is the most common monosaccharide consumed by humans, and its metabolism has been discussed extensively. Overview
BIOCHEMISTRYANDMOLECULARBIOLOGYOverviewHowever, two other monosaccharides-fructose andgalactose-occur in significant amounts in the diet(primarily in disaccharides), and make importantcontributions to energy metabolism.Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY However, two other monosaccharides-fructose and galactose-occur in significant amounts in the diet (primarily in disaccharides), and make important contributions to energy metabolism. Overview
BIOCHEMISTRYANDMOLECULARBIOLOGYOverviewIn addition, galactose is an important componentof cell structural carbohydrates.Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY In addition, galactose is an important component of cell structural carbohydrates. Overview
3FRUCTOSEGLYCOLYSISMETABOLISMUnlesstheintrecellularBIOCHEMISTRYANDMOLECULARBIOLOGYconcentration of fructosebecomes unusually high,hexokinase is saturated withandphosphorylatesglucoseratherthanfructoseCH.OHCH.OH=0C=0HO-O-HC-HHO-H-C-OHH-C-OHH-C-OHH-C-OHCH.O-CH,OHHeonnese.7FructoseFructose6-phosphateFructose metabolismCATP-ATPFructokinasePnosproriucioknaseADPADPCH2O-PCHO-P0-0COHO-O-HHO-C-HH-C-OHH-C-OHH-C-OHH-C-OHCH,OHCH.O-PFructoseFructose1-phosphate1,6-bisphosphateAdpiaseA,BCAdoaseB00C-HO-HHH-C-OHH-C-OHH-C-OHC4OCHO-PCH.OHCH2O-PGlyceraldehydeGlyceraldehyde3-phosphateDihydroxyacetonephosphateFigure12.2nent of Biochemistry and Molecular Biology,Medicine SchoolPhosphorylationproductsoffructoseand their cleavage
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Fructose metabolism