BIOCHEMISTRYANDMOLECULARBIOLOGY22ChapterAmino acids: metabolismof carbon skeletonsDepartmentof Biochemistry and Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Amino acids: metabolism of carbon skeletons Chapter 22
BIOCHEMISTRYANDMOLECULARBIOLOGYl. Catabolism of the carbonskeletonsofaminoacids>The catalolism of the carbon skeletons converges toform seven products: oxaloacetate, a-ketoglutarate pyruvate, fumarate, acetyl CoA, acetoacetyl CoA, andsuccinyl CoA.> These products enter the pathways of intermediarymetabolism , Resulting either in the synthesis of glucoseor lipid ,or in the production of energy through theiroxidation to CO2 and water by the citric acid cycle.Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 1. Catabolism of the carbon skeletons of amino acids ➢The catalolism of the carbon skeletons converges to form seven products: oxaloacetate, α-ketoglutarate , pyruvate, fumarate, acetyl CoA, acetoacetyl CoA, and succinyl CoA. ➢ These products enter the pathways of intermediary metabolism , Resulting either in the synthesis of glucose or lipid ,or in the production of energy through their oxidation to CO2 and water by the citric acid cycle
生BIOCHEMISTRYANDMOLECULARBIOLOGY>Amino acids can be classified as essential ornonessential according to whether or not they can besynthesized in humans.>Amino acids can be classified as ketogenic orglucogenic according to the nature of their metabolicend products.Department ofBiochemistry and Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢Amino acids can be classified as essential or nonessential according to whether or not they can be synthesized in humans. ➢Amino acids can be classified as ketogenic or glucogenic according to the nature of their metabolic end products
BIOCHEMISTRYANDMOLECULARBIOLOGYGlucogenicGlucogenicandKetogenicKetogenicTyrosineNonessentialAlanine;AsparagineAspartate;CysteineGlutamate;GlutamineGlycine;ProlineSerineEssentialArginine;IsoleucineLeucineHistidinePhenylalanineLysineMethionine,TryptophanThreonineValineDepartment ofBiochemistryandMolecularBiology,MedicineSchoo
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Glucogenic Glucogenic and Ketogenic Ketogenic Nonessential Alanine ;Asparagine Aspartate;Cysteine Glutamate;Glutamine Glycine;Proline Serine Tyrosine Essential Arginine; Histidine Methionine, Threonine Valine Isoleucine Phenylalanine Tryptophan Leucine Lysine
BIOCHEMISTRYANDMOLECULARBIOLOGYEssential amino acids: these amino acids cannotbe synthesized in humans (or cannot be produced insufficient amounts), and therefore must obtained inthe diet in order for normal protein synthesis to occur.Department ofBiochemistry and Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Essential amino acids: these amino acids cannot be synthesized in humans (or cannot be produced in sufficient amounts), and therefore must obtained in the diet in order for normal protein synthesis to occur