Pathogenesis of peptic Treatment approaches ule cers ()Increased gastric (REducing secretion of acid secretion gastric acid or neutralizing the acid (2)Infection with gram negative helicobacter (2)Eradicating H pylon pylon infection (3)Inadequate mucosal defense against gastric (3)Protecting the gastric acid mucosa from damage
Pathogenesis of peptic ulcers Treatment approaches (1)Increased gastric acid secretion (3)Inadequate mucosal defense against gastric acid (2)Infection with gramnegative Helicobacter pylori (1)Reducing secretion of gastric acid or neutralizing the acid (3)Protecting the gastric mucosa from damage (2)Eradicating H. pylori infection
3. Drugs used for peptic ulcers (1) Antacids: neutralizing the acid (2) Drugs suppressing gastric acid secretion MUscarinic receptor antagonists 2H, receptor antagonists @Gastrin receptor antagonists 4H+-K+-ATPase inhibitors(proton pump inhibitors) (3)Antimicrobial drugs(Helicobacter pylori (4 )Mucosal protective drugs
(1) Antacids: neutralizing the acid (2) Drugs suppressing gastric acid secretion ①Muscarinic receptor antagonists ②H2 receptor antagonists ③Gastrin receptor antagonists ④ H+ -K+ -ATPase inhibitors (proton pump inhibitors) (3)Antimicrobial drugs (Helicobacter pylori) (4)Mucosal protective drugs 3.Drugs used for peptic ulcers
§(1) Antacids (Weak bases) Chemistry of antacids Salts of aluminum(aluminum hydroxide Salts of magnesium(carbonate hydroxide trisilicate), aluminum magnesium carbonate (ALMg(OH)16CO3 4H,O) calcium(carbonate) sodium(bicarbonate
§ (1) Antacids (Weak bases) Chemistry of antacids: Salts of aluminum (aluminum hydroxide) , Salts of magnesium (carbonate, hydroxide, trisilicate) , aluminum magnesium carbonate (Al2Mg6 (OH)16CO3·4H2O) calcium(carbonate) sodium (bicarbonate)
§(1) Antacids Receptors lon channel ETC Parietal cell ITC acetycholine Luminal membrane ATP histamine X/Antacids 3 (the proton pymp H2T→ CAMPE令cH, K-ATPase C Gastric 入 K gastrin G Cell membrane Mechamism of action
§ (1) Antacids × Antacids Mechamism of action (the proton pump)
(ANtacids 1. Pharmacological effect Neutralizing gastric acid, diminish gastric acidity and inactivate pepsin(胃蛋白酶) activity The effect depends on the dose and dosing frequency. Starting effect within 5-15 min after taking the drugs. 2. Clinical uses Commonly used for acid-peptic disorders(peptic ulcer) gastritis, duodenitis
(1) Antacids 1. Pharmacological effect Neutralizing gastric acid, diminish gastric acidity and inactivate pepsin（胃蛋白酶）activity The effect depends on the dose and dosing frequency. Starting effect within 5-15 min after taking the drugs. 2. Clinical uses Commonly used for acid-peptic disorders (peptic ulcer), gastritis, duodenitis