2. Gastric acid secretion and regulation Gastric cells of mucosa (1Surface epithelial cells(secrete mucus) (2)Mucus neck cells(secret mucus and are the source of proliferating cells) (3)Chief cells(secret pepsinogens) (4) G cells(release gastrin in the antrum (5)Parietal cells in the gastric fundus( secrete HCI and intrinsic factor
2. Gastric acid secretion and regulation Gastric cells of mucosa (1)Surface epithelial cells (secrete mucus) (2)Mucus neck cells (secret mucus and are the source of proliferating cells); (3)Chief cells (secret pepsinogens) (4)G cells (release gastrin in the antrum); (5)Parietal cells in the gastric fundus ( secrete HCl and intrinsic factor)
2. Gastric acid secretion and regulation Receptors ETC lc on channe Parietal cell ITC acetycholine Luminal membrane M ATP histamin 3 (the proton pump)4 H H2T→AMP今H,KAPa Gastric K lumen gastrin K G lon channels Basolateral membane +4 Cell membrane
2. Gastric acid secretion and regulation Basolateral membane (the proton pump)
Preepitheial MUCUS H Pepsin Lumen BicArbonate pH1-2 Surface acttm Mucus ge HCO H7 HCO Eoithelial SEprho u Celluler res sarca Restitution Prostaglandins Growth factors Prostaglandins Microciroutfon Cell proiferation Subepwheiak Blood flow Leukocy Mucus-bicarbonate barrier
Mucus-bicarbonate barrier
Helicobacter pylori the bacterium causing peptic ulcer disease rous Infection rects the aer pa c stomach Ulcer Gasc summation mwy ad lo duodeni o waste ucet Severe completions caude Hesco cher Eylon ing scer and uiere increased aed aton Duodenal ulcer Inflammation of the gastre muc mmatory Helicobacter pylori infection
Helicobacter pylori infection
2. Pathogenesis of peptic ulcers Aggressive factors Defensive factors Gastric acid Mucus epsin bicarbonate Helicobacter pylori Mucosa hydrochloric acid pepsin(protease) stomach lining
Gastric acid Pepsin Helicobacter pylori Mucus bicarbonate Mucosa 2.Pathogenesis of peptic ulcers Aggressive factors Defensive factors