【Adverse effect】 1.Gastric discomfort:Nausea,vomiting,and diarrhea 2.Bony structures and Teeth discoloration and hypoplasia of the teeth and a temporary stunting of growth 3.Fatal hepatotoxicity:in pregnant women 4.Phototoxicity:severe sunburn
【Adverse effect 】 1. Gastric discomfort: Nausea, vomiting, and diarrhea 2. Bony structures and Teeth :discoloration and hypoplasia of the teeth and a temporary stunting of growth 3. Fatal hepatotoxicity: in pregnant women 4. Phototoxicity: severe sunburn
4.Vestibular problems:dizziness,nausea,vomiting 5.Pseudotumor cerebri:Benign intracranial hypertension headache,blurred vision 6.Superinfections:pseudomembranous enterocolitis Vancomycin:
4. Vestibular problems: dizziness, nausea, vomiting 5. Pseudotumor cerebri: Benign intracranial hypertension , headache , blurred vision 6. Superinfections: pseudomembranous enterocolitis Vancomycin:
Section 2 Chloramphenicol Antibacterial action 1.Chloramphenicol is either bacteriostatic or bactericidal 2.It is active against both aerobic and anaerobic gram- positive and gram-negative organisms 3.It has effective against rickettsiae,helicoids,Chlamydia and mycoplasma
Section 2 Chloramphenicol 【 Antibacterial action】 1. Chloramphenicol is either bacteriostatic or bactericidal 2. It is active against both aerobic and anaerobic grampositive and gram-negative organisms 3. It has effective against rickettsiae, helicoids, Chlamydia and mycoplasma
【Mechanism of action】 Chloramphenicol(50S,A) Peptidyl transferase
P A P A Chloramphenicol(50S,A) 【Mechanism of action】
【pharmacokinetics】 1.Chloramphenicol may be administered either intravenously or orally 2.It penetrate blood-brain barrier,placental barrier, blood-ocular barrier 3.It is inactivated by conjugation with glucuronic acid in liver,secreted by the renal tubule
【pharmacokinetics】 1. Chloramphenicol may be administered either intravenously or orally 2. It penetrate blood-brain barrier, placental barrier, blood-ocular barrier 3. It is inactivated by conjugation with glucuronic acid in liver, secreted by the renal tubule