Terms and definition ●●●● ●●0●● ●●●● 9. Concentration Dependent killing: situation in which the。。。 bactericidal activity of a drug depends by how much the drug concentration exceeds the Minimum inhibitory concentration. e. g aminoglycosides and quinolones(有长PAE,首次接触效应) 10. Time-dependent killing: situation in which the bactericidal activity of a drug depends how long the drug concentration exceeds the minimum inhibitory concentration of the organism in question.eg.β- lactams and vancomycin(无首次接触效应) 11. Post antibiotic affect(PAE抗生素后效应): Persistence of suppression of bacterial growth after limited exposure to an antimicrobial agent. e.g. aminoglycosides, quinolones 12. First expose effect(首次接触效应): aminoglycosides
9. Concentration Dependent killing: situation in which the bactericidal activity of a drug depends by how much the drug concentration exceeds the Minimum inhibitory concentration. e.g. aminoglycosides and quinolones（有长PAE，首次接触效应） 10. Time-dependent killing: situation in which the bactericidal activity of a drug depends how long the drug concentration exceeds the Minimum inhibitory concentration of the organism in question. e.g. -lactams and vancomycin （无首次接触效应） 11. Post antibiotic affect (PAE 抗生素后效应) : Persistence of suppression of bacterial growth after limited exposure to an antimicrobial agent. e.g. aminoglycosides，quinolones 12. First expose effect (首次接触效应): aminoglycosides Terms and definition
Classification and mechanism of action Cell wall synth i cycloserine ① I vancomycin I DNA replication (DNA gyrase bacitracin penicillins (4 I nalidixic acid halo ni quinolone DNA DNA-dependent RNA polymerase rifampin Folic acid metabolism THFA mRNA I trimethoprim-t maN Ribosomes I sulfonamides-t DHFA 屬屬 ebbott Protein synthesis (50s inhibitors) erythromycin periplasmic space 3 chloramphenicol B-lactamases clindamycin aminoglycoside Protein synthesis modifying PABA (30s inhibitors) enzymes tetracycline Cell membrane ② I polymyxins streptomycin chloramphenicol gentamicin, tobramycin transacetylase amikacin
① ② ③ ④ ⑤ Classification and mechanism of action
Penicillins Gram Positive Gram Negative Specific Porin Channel- O Polysaccharide n Lipopoly Channe Lipid A saccharide Protel (LPS) Teichoic 分 Lactamase Acid Oute Peptide Membrane qh Cell wall Lipoprotein Periplasmic Peptide Space glycan 阝La Plasma Membrane & Penicillin Binding Protein(PBP) Phospholipid Penicillin Binding Protein(PBP) Proteins e Comparison of the structure and composition of G+/G- cell walls
⚫ Comparison of the structure and composition of G+/ G- cell walls. Penicillins