●●● ●●●● ●●●●● ●●●● 2. Terms and definition ●●0●● ●●●● ●●●● (1) Antibacterial drugs(抗菌药) Substances that can kill bacteria and/or inhibit its growth IncludIng ① Antibiotics(抗生素) sYnthetic antimicrobial agents such as sulfonamides(磺胺类)and quinolones(喹诺酮类),etc
2. Terms and definition: (1)Antibacterial drugs(抗菌药): Substances that can kill bacteria and/or inhibit its growth. including: ①Antibiotics(抗生素); ②Synthetic antimicrobial agents, such as sulfonamides (磺胺类) and quinolones (喹诺酮类), etc
Terms and definition ●●●● ●●0●● ●●●● ●●●● (2) Antibiotics(抗生素) Substances produced by various species of microorganisms(bacteria fungi, actinomyces, etc. ), which can kill other microorganisms or inhibit their growth
(2)Antibiotics(抗生素): Substances produced by various species of microorganisms (bacteria, fungi, actinomyces, etc.), which can kill other microorganisms or inhibit their growth. Terms and definition
Terms and definition ●●●●● ●●●● ●●0●● ●●●● ●●●● (3) Chemotherapeutic index(化疗指数) LD5O/ED50, or LD5/ED95 (4) Antibacterial spectrum(抗菌谱) (5) Bacteriostatic drugs(抑菌药) 6) Bactericidal drugs(杀菌药)
(3)Chemotherapetic index (化疗指数) : LD50/ED50, or LD5/ED95 (4)Antibacterial spectrum(抗菌谱); (5)Bacteriostatic drugs(抑菌药); (6)Bactericidal drugs(杀菌药); Terms and definition
Log cfu (number of bacteria Terms and definition ●●●● 108 ●●0●● antimicrobial ●●●● ●●●● agent agents 106 Bacteriostatic 109 Bactericidal 102 7 Time (arbitrary units)
agents Terms and definition
●●● Antimicrobial Susceptibility Testing ●●●● ●●●●● ●●●● ●●0●● A. Dilution test ●●●0 Antimicrobial drug concentrations (ug/ml) ●●●● No visible growth 64 32 16 0.5 MIC 4 ug/ml 7. Minimum inhibitory Agar test concentration(MIC) 8. Minimum bactericidal concentration(MBC): 99.9% decrease in growth MBC= 32 over 24 hours gar plate
Antimicrobial Susceptibility Testing 7. Minimum inhibitory concentration (MIC) 8. Minimum bactericidal concentration (MBC): 99.9% decrease in growth over 24 hours