Narcotic Antitussives Drotebanol (Oxymethebanol) 羟蒂巴酚 OH A morphinan derivative that acts as an opiod agonist
Drotebanol (Oxymethebanol) 羟蒂巴酚 A morphinan derivative that acts as an opiod agonist Narcotic
Narcotic Antitussives Drotebanol s Pharmacological effects 6 cough suppressant effects: around 10x more potent than codeine o analgesic effects: several times stronger than codeine, but weaker than morphine s In animal studies it was found to be moderately addictive and produced limited physical dependence, but not as severe as that seen with morphine or pethidine It was previously marketed for human use under the brand name metebany l, although it is now no longer used in medicine
Drotebanol cough suppressant effects : around 10x more potent than codeine. analgesic effects : several times stronger than codeine, but weaker than morphine v In animal studies it was found to be moderately addictive and produced limited physical dependence, but not as severe as that seen with morphine or pethidine v It was previously marketed for human use under the brand name Metebanyl, although it is now no longer used in medicine. Narcotic
Narcotic Antitussives Pho| codine(福尔可定) HO an opioid cough suppressant
Pholcodine（福尔可定） Narcotic an opioid cough suppressant
Narcotic Antitussives Pholcodine Pharmacological effects o Its cough suppressant effects is similar with codeine o6 mild sedative effect oo little or no analgesic effects oo lower potential for dependence o Mechanism of action acts primarily on the central nervous system(CNS), causing depression of the cough reflex, partly by a direct effect on the cough centre in the medulla ◆ Side effects os Dizziness os Gastrointestinal disturbances such as nausea or vomiting 6 constipation, drowsiness, excitation, ataxia and respiratory depression atter large dose s) G Increased levels of IgE-antibodies o Increase the risk of anaphy laxis to neuromuscular blocking agents used during anaesthesia
Pholcodine Its cough suppressant effects is similar with codeine mild sedative effect little or no analgesic effects lower potential for dependence It acts primarily on the central nervous system (CNS), causing depression of the cough reflex, partly by a direct effect on the cough centre in the medulla. Dizziness Gastrointestinal disturbances such as nausea or vomiting. constipation, drowsiness, excitation, ataxia and respiratory depression ( after large doses) Increased levels of IgE-antibodies, Increase the risk of anaphylaxis to neuromuscular blocking agents used during anaesthesia. Narcotic
Non- Narcotic Antitussives Dextromethorphan右美沙芬,D×M CH3( H3 c0 N—CH3 N—CH HO Dextromethorphan Codeine
O N CH3 HO H3CO Antitussives