Pharmacology for cardiovascular system Part 3 Antihypertensive Drugs Weiping Zhang, MD PhD. Associate professor Dept Pharmacology, Medical schooL, Zhejiang University weiping601@zju.edu.cn 2010.6.21
Weiping Zhang, MD. PhD. Associate professor Dept. Pharmacology, Medical School, Zhejiang University weiping601@zju.edu.cn 2010.6.21 Part 3 Antihypertensive Drugs Pharmacology for cardiovascular system
Antihypertensive Drugs Overview I. Basic pharmacology of antihypertensive drugs 1. Drugs that alter sodium water balance 2. Drugs that alter sympathetic nervous system function; 3. Vasodilators: 4. Agents that block raas II. Clinical pharmacology of antihypertensive agents
Blood Pressure and risk for Coronary Heart Disease in Men 60 60 50 50 E豆 40 40 Age65-94 Age65-94 30 30 320 Age 35-6. 0g 10 10 A9e35-64 三0 <120120-140-160-180+ <7575-85-95-105 139159179 8494104 Systolic blood pressure(mmHg Diastolic blood pressure(mmHg) Based on 30 year follow-up of Framingham Heart Study subjects free of coronary heart disease (CHD) at baseline Framingham Heart Study, 30-year Follow-up NHLBI, 1987
0 10 20 30 40 50 60 <120 120- 139 140- 159 160- 179 180+ 0 10 20 30 40 50 60 <75 75- 84 85- 94 95- 104 105+ A g e - a d j u s t e d a n n u al in cid e n c e o f C H D p e r 1 0 0 0 Based on 30 year follow-up of Framingham Heart Study subjects free of coronary heart disease (CHD) at baseline Systolic blood pressure (mmHg) Diastolic blood pressure (mmHg) Framingham Heart Study, 30-year Follow-up. NHLBI, 1987
JNC-7 Definitions(2003) Systolic Diastolic Category (mm Hg)(mm Hg) Twice as likely Normal <120 <80 to progress to Prehypertension 120-139<80-89 hypertension Hypertension 140-159 90-99 (Stage D) Hypertension 160 (Stage D) 100 JnC-8 Expected Availability for Public Review and Comment: Spring 2011 Expected Release date: Fall 2011
Category Systolic (mm Hg) Diastolic (mm Hg) Normal < 120 < 80 Prehypertension 120 – 139 < 80 – 89 Hypertension (Stage I) 140 – 159 90 – 99 Hypertension (Stage II) 160 100 JNC－8 Expected Availability for Public Review and Comment: Spring 2011 Expected Release Date: Fall 2011
Causes of death in patients with htn Kidney Other MI or che F allure Stroke 15% ■ Kidney failure ■ Other MI or che Stroke 33%
MI or CHF 50% Stroke 33% Kidney Failure 15% Other 2% MI or CHF Stroke Kidney Failure Other