调血脂药 (Lipid-regulators Yun-BiLu, PhD 卢韵碧 Dept of Pharmacology, School of Medicine, Zhejiang University yunbi@zju.edu.cn 2017.67
调血脂药 （Lipid-regulators） Yun-Bi Lu, PhD 卢韵碧 Dept. of Pharmacology, School of Medicine, Zhejiang University yunbi@zju.edu.cn 2017.6.7
正常动脉脂肪线样硬化化局部症状血管闭塞 O⊙②ee Types of human brain stroke Arteries become narrowed and blood flow decreases in arteriosclerosis Buid up of fatty stances n the ∠动脉粥样硬化景致动脉管腔狭窄 atherosclerosis
plas Include Triglyceride(TG):三酰甘油 Cholesterol(TC):胆固醇 Cholesterol ester(CE):胆固醇酯 Free cholesterol(FC):游离胆固醇 Others phospholipids(PL):磷脂 free fatty acid(FFA):游离脂肪酸 Y Lipids apolipoprotein(apoprotein, apo)=lipoprotein 血脂+载脂蛋白=脂蛋白(溶于血浆,可进行转运与代谢) √ApoA,B,c,D,E:结合于转运脂质
Lipids include: • Triglyceride (TG)：三酰甘油 • Cholesterol (TC)：胆固醇 Cholesterol ester (CE)：胆固醇酯 Free cholesterol (FC)：游离胆固醇 • Others phospholipids(PL)：磷脂 free fatty acid (FFA)：游离脂肪酸 ✓Lipids + apolipoprotein (apoprotein, Apo) = lipoprotein 血脂 + 载脂蛋白 = 脂蛋白 （溶于血浆，可进行转运与代谢） ✓Apo A, B, C, D, E: 结合于转运脂质
apoproteins include Chylomicron(CM):乳糜微粒 Very Low Density Lipoprotein(LDL):极低密度脂蛋白 Low Density Lipoprotein(LDL):低密度脂蛋白 High Density Lipoprotein(HDL):高密度脂蛋白 Intermediate Density Lipoprotein(DL):中间密度脂蛋白 Y Lipids apolipoprotein(apoprotein, apo)=lipoprotein 血脂+载脂蛋白=脂蛋白(溶于血浆,可进行转运与代谢) √ApoA,B,c,D,E:结合于转运脂质
Lipoproteins include: • Chylomicron (CM):乳糜微粒 • Very Low Density Lipoprotein (VLDL)：极低密度脂蛋白 • Low Density Lipoprotein (LDL)：低密度脂蛋白 • High Density Lipoprotein (HDL)：高密度脂蛋白 • Intermediate Density Lipoprotein (IDL)：中间密度脂蛋白 ✓Lipids + apolipoprotein (apoprotein, Apo) = lipoprotein 血脂 + 载脂蛋白 = 脂蛋白 （溶于血浆，可进行转运与代谢） ✓Apo A, B, C, D, E: 结合于转运脂质
LIPOPROTEINS 0.95 VLDL VLDL Remnants Chylomicron LDL 1.06 10 HDL 00 Diameter (nm)
1.20 1.10 1.06 1.02 1.006 0.95 5 10 20 40 60 80 1000 Chylomicron Remnants VLDL IDL LDL HDL2 HDL3 Diameter (nm) Density (g/ml) VLDL Remnants LIPOPROTEINS