Antipyretic-Analgesic and Antiinflammatory Drugs 解热镇痛药 汤慧芳 浙江大学医学院 药理系 2018-11-7
汤慧芳 浙江大学医学院 药理系 2018-11-7 Antipyretic-Analgesic and Antiinflammatory Drugs 解热镇痛药
A. General Pharmacological properties 1. Inhibition of prostaglandin synthesis inhibiting cyclooxygenase(CoX,环氧酶) decreasing the synthesis of PGs and TXA2 resulting antipyretic, analgesic, and anti inflammatory effects Non-steroidal anti-inflammatory drugs NSAIDS,非甾体抗炎药)。 大亭院
1. Inhibition of prostaglandin synthesis inhibiting cyclooxygenase (COX，环氧酶), decreasing the synthesis of PGs and TXA2 , resulting antipyretic, analgesic, and antiinflammatory effects Non-steroidal anti-inflammatory drugs (NSAIDs, 非甾体抗炎药）。 A. General Pharmacological properties
Stimulus Disturbance of cell membranes Phospholipids Phospholipase inhibitors Corticosteroids Phospholipase Fatty acid substitution(diet) Arachidonic acid Lipoxygenase inhibitors Lipoxygenase Cyclooxygenase NSAID. ASA Leukotrienes eceptor antagonists LTBA LTC//DA/E4 ( Prostaglandins Thromboxane Prostacyclin Phagocyte Alteration of vascula permeability, bronchial activation constriction, increased Leukocyte modulation secretion Colchicine Inflammatio Bronchospasm Inflammation congestion, mucous plugging I
A.General Pharmacological properties 2. Antipyretic effects Inhibition of pce 2 production in the hypothalamus induced by endogenous pyregens after pathological stimuli -y temperature↓ notes: symptomatic control only, not be indicated in all patients with fever The effect on body temperature is different from that of chlorpromazine 大亭院
2.Antipyretic effects Inhibition of PGE2 production in the hypothalamus induced by endogenous pyregens after pathological stimuli → temperature notes: symptomatic control only, not be indicated in all patients with fever. The effect on body temperature is different from that of chlorpromazine. A. General Pharmacological properties
Comparison of properties of two types of drugs 解热镇痛药 氯丙嗪 作用机制|抑制前列腺素合成,使|抑制下丘脑体温调节中枢, 散热增加而解热 使其调节功能减弱,不能随 外界温度变化而调节体温 作用 只能使升高的体温降到氯丙嗪配合物理降温,不仅 正常 可使升高的体温降到正常, 也可使正常体温降到正常以 下 用途用于各种发热 用于低温麻醉、人工冬眠 不良反应胃肠道反应等 锥体外系统反应等 满大告学流
解热镇痛药 氯丙嗪 作用机制 抑制前列腺素合成，使 散热增加而解热 抑制下丘脑体温调节中枢， 使其调节功能减弱，不能随 外界温度变化而调节体温 作用 只能使升高的体温降到 正常 氯丙嗪配合物理降温，不仅 可使升高的体温降到正常， 也可使正常体温降到正常以 下 用途 用于各种发热 用于低温麻醉、人工冬眠 不良反应 胃肠道反应等 锥体外系统反应等 Comparison of properties of two types of drugs