B. Mucoactive drugs Mucolytic drugs(粘痰溶解药) N- Acetylcysteine乙酰半胱氨酸 Erdosteine厄多司坦 Dextran Heparin Macokinetics drugs(痰液调节药) Bromhexine溴己新 Ambroxol氨溴索 Surfactants
B. Mucoactive drugs Mucolytic drugs(粘痰溶解药) N-Acetylcysteine 乙酰半胱氨酸 Erdosteine 厄多司坦 Dextran Heparin Mucokinetics drugs（痰液调节药） Bromhexine 溴己新 Ambroxol 氨溴索 Surfactants
Expectorants Ammonium chloride氯化铵 恶心性祛痰药的代表药 This causes the production of excess respiratory tract fluid which presumably is easier to cough up. Ammonium salts are an irritant to the gastric mucosa and may induce nausea and vomiting
Ammonium chloride 氯化铵 • 恶心性祛痰药的代表药 • This causes the production of excess respiratory tract fluid which presumably is easier to cough up. • Ammonium salts are an irritant to the gastric mucosa and may induce nausea and vomiting. Expectorants
Expectorants Guaifenesin愈创木酚甘油醚 刺激性祛痰药的代表药 Effect and mechanism of action increasing the volume and reducing the viscosi ity of secretions in the trachea and bronck hi stimulates the flow of respiratory tract secretions allowing ciliary movement to carry the loosened secretions upward toward the pharynx increase the efficiency of the cough reflex facilitate removal of the secretions
Guaifenesin 愈创木酚甘油醚 • 刺激性祛痰药的代表药 • Effect and mechanism of action – increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. – stimulates the flow of respiratory tract secretions, – allowing ciliary movement to carry the loosened secretions upward toward the pharynx – increase the efficiency of the cough reflex – facilitate removal of the secretions Expectorants
MI ucoreguITor Carbocisteine羧甲司坦 HO N Carbocysteine(mucoregulator Carbocisteine is produced by alkylation of cysteine with chloroacetic acid Pharmacological effect Reduces the viscosity of sputum allowing the sufferer to bring up sputum more easily Carbocisteine should not be used with antitussives (cough suppressants)or medicines that dry up bronchial secretions
Carbocysteine 羧甲司坦 • • Carbocisteine is produced by alkylation of cysteine with chloroacetic acid. • Pharmacological effect – Reduces the viscosity of sputum allowing the sufferer to bring up sputum more easily. • Carbocisteine should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions. Mucoregultor
Mucolytic drugs N- Acetylcysteine N乙酰半胱氨酸NAC OH CH3 N-Acetylcysteine(mucolytic) O Pharmacological effect Antioxidant and liver protecting effects--a dietary supplement Breaks disulfide bonds in mucus and liquefies it, making it easier to cough up. --cough therapy
N-Acetylcysteine N乙酰半胱氨酸,NAC • Pharmacological effect: – Antioxidant and liver protecting effects-- a dietary supplement : – Breaks disulfide bonds in mucus and liquefies it, making it easier to cough up.-- cough therapy: Mucolytic drugs