Bronchodilators (支气管扩张药) Huifang Tang(汤慧芳 Department of pharmacology Zhejiang university, school of Medicine tanghuifang@ziu.edu.cn
Bronchodilators (支气管扩张药) Huifang Tang (汤慧芳) Department of Pharmacology Zhejiang university, school of Medicine tanghuifang@zju.edu.cn
Drugs acting on respiratory system Cough antitussive drugs centrally acting peripherally acting Sputum expectorant drugs sputum-diluting drugs mucolytic drugs Asthma antiasthmatic drugs Bronchodilators β receptor agonists theophyllines muscarinic antagonists Anti-inflammatory drugs glucocorticosteroids mediator release inhibitors
Drugs acting on respiratory system Cough antitussive drugs centrally acting peripherally acting Sputum expectorant drugs sputum-diluting drugs mucolytic drugs Asthma antiasthmatic drugs Bronchodilators receptor agonists theophyllines muscarinic antagonists Anti-inflammatory drugs glucocorticosteroids mediator release inhibitors
Why asthma makes it hard to breathe Air enters the respiratory system from the nose and mouth and travels through the bronchial tubes. In a non-asthmatic person, In an asthmatic person, the the muscles around the muscles of the bronchial tubes bronchial tubes are relaxed tighten and thicken, and the and the tissue thin air passages become allowing for easy inflamed and mucus- filled, makir difficult for air to move A Inflamed bronchial tube of an asthmatic Normal bronchial tube
Antiasthmatic drugs Immunological and non-immunological stimuli Airway inflammation bronchoconstriction glucocorticosteroids B2receptor agonists Pheophyll Ine Di Isodium cromoglycate Muscerinic antagonists Leukotriene modifiers Airway hyperresponsiveness A Wheezing(asthmatic symptoms)
Antiasthmatic drugs Airway inflammation bronchoconstriction Airway hyperresponsiveness Immunological and non-immunological stimuli Wheezing (asthmatic symptoms) glucocorticosteroids Disodium cromoglycate Leukotriene modifiers 2 receptor agonists Theophylline Muscerinic antagonists
CNS Airway Vag afferent Vagal efferent Tissue response cells sory receptor (mast ce or eosinophi Mediators from whaled intan response c Mucosa … lonic fiber Transmitter(ACh) Postgang onic neuron L Smooth musce cells