Thyroid hormones and antithyroid drugs CEAN KAYA其 Dept of Pharmacology Shi-Hong Zhang(张世红 shzhang713@zju.edu.cn
Thyroid hormones and antithyroid drugs Dept of Pharmacology Shi-Hong Zhang (张世红) shzhang713@zju.edu.cn
Thyroid gland Thyroid gland Parathyroid glands Back view Front view
Front view Thyroid gland
Thyroid hormones 1. Uptake of iodide 2. Oxidation of iodide(peroxidase) and iodination and coupling of tyrosine 3. Formation of thyroxine(t4) and triiodothyronine (T3) from iodotyrosine 4. Secretion of thyroid hormones(proteolytic enzymes) 5. Regulation by thyroid stimulating hormone(TSH), T4s
Thyroid hormones 1. Uptake of iodide 2. Oxidation of iodide (peroxidase) and iodination and coupling of tyrosine 3. Formation of thyroxine (T4 ) and triiodothyronine (T3 ) from iodotyrosine 4. Secretion of thyroid hormones (proteolytic enzymes) 5. Regulation by thyroid stimulating hormone (TSH), T4 , T3
NH CH -CH-COOH L-tyrosine CH.-CH-COOH HO >CH2-CH-COOH monoiodo tyrosine(MIT) diiodotyrosine(DIT) NH 2 HO CH2-CH-COOH 3, 5. 3'-triodothyronine (T3) NH CH2-CH-COOH 3, 5, 3, 5, tetraiodothyronine(Ta) thyroxine)
Acute Circadian and psychosis pulsatile rhythms Severe Cold H Hypothalamus Somato /(Statin Corticoids 打TRH dopamine AP T4,T3 TSH Thyroid