Chapter 4 Factors Influencing Drug Effects a Patient factors u Drug Factors
Chapter 4 Factors Influencing Drug Effects Patient Factors Drug Factors
Drug Patient Dosage regimen drugs, doses, intervals, duration Efficacy Adjustment adverse effects, concentrations Doctor
Drug Patient Doctor Efficacy, adverse effects, concentrations Adjustment Dosage regimen drugs, doses, intervals, duration
PRESCRIBED DOSE patient compliance medication errors ADMINISTERED DOSE rate and extent of absorption body size and composition distribution in body fluids binding in plasma and tissues rate of elimination physiological variables CONCENTRATION pathological factors AT LOCUS genetIc factors OF ACTION interaction with other drugs development of tolerance drug-receptor interaction functional state placebo effects INTENSITY OF EFFECT
Parta Patient Factors u 1. Physiological Factors 口11Age MiSS MET D Children D Sensitivity to drugs u Pharmacokinetic properties 口 Elderly 日 Sensitivity to drugs U Pharmacokinetic properties
Part A Patient Factors 1. Physiological Factors 1.1 Age Children Sensitivity to drugs Pharmacokinetic properties Elderly Sensitivity to drugs Pharmacokinetic properties
Infants Young adults Elderly Total body water(%) of body Fraction of ry tiss metabolism of drug Renal drug elimination