Mucolytic drugs Erdosteine厄多司坦 it is a thiol derivative Action Mucolytic free radical scavenging activity modulates mucus production and viscosity increases mucociliary transport, It also exhibits inhibitory activity against the effects of free radicals produced by cigarette smoke Clinical use chronic obstructive lung disease: reduced cough both frequency and acebo and reduced the adhesivity of sputum more effectively thar bromhexine 30 mg twice daily Co-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier and more pronounced amelioration of clinical symptoms compared with placebo a low incidence of adverse events, most of which are gastrointestinal and generally mild
Erdosteine 厄多司坦 • it is a thiol derivative. Action • Mucolytic • free radical scavenging activity. • modulates mucus production and viscosity • increases mucociliary transport, • It also exhibits inhibitory activity against the effects of free radicals produced by cigarette smoke. Clinical use: • chronic obstructive lung disease : reduced cough (both frequency and severity) and sputum viscosity more quickly and more effectively than placebo and reduced the adhesivity of sputum more effectively than bromhexine 30 mg twice daily. • Co-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier and more pronounced amelioration of clinical symptoms compared with placebo. • a low incidence of adverse events, most of which are gastrointestinal and generally mild. Mucolytic drugs
Mucokinetic drugs Ambroxol(氨溴索沐舒坦) OH Br N H Ambroxol(mucokinetic 全肺动力型排痰剂
Ambroxol ( 氨溴索,沐舒坦) Mucokinetic drugs 全肺动力型排痰剂
Mucokinetic drugs Mucoactive action secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract stimulates synthesis and release of surfactant by type Ii pneumocytes es promotes mucus clearance facilitates expectoration and eases productive cou lg 6 local anaesthetic effect a very potent inhibitor of the e neuronal nat channels es anti-inf lammatory properties Clinical use upper respiratory tract infections and other lung pr roblems, including chronic inflammatory pulmonary conditions
Mucoactive action secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract stimulates synthesis and release of surfactant by type II pneumocytes. promotes mucus clearance, facilitates expectoration and eases productive cough local anaesthetic effect a very potent inhibitor of the neuronal Na+ channels anti-inflammatory properties Clinical use: upper respiratory tract infections and other lung problems, including chronic inflammatory pulmonary conditions; Mucokinetic drugs
Mucokinetic drugs Ambroxol Side effects Gastrointestinal Side Effects including diarrhea, heartburn, indigestion, and occasionally nausea and vomiting Allergic Reactions rarely mainly involve skin rashes hives and dermatitis, as well as possible swelling Intravenous side Effects Intravenous ambroxol has been associated with chills. intense headaches, shortness of breath and weakness
Ambroxol Side Effects Gastrointestinal Side Effects • including diarrhea, heartburn, indigestion, and occasionally nausea and vomiting. Allergic Reactions • rarely, mainly involve skin rashes, hives and dermatitis, as well as possible swelling. Intravenous Side Effects • Intravenous ambroxol has been associated with chills, intense headaches, shortness of breath and weakness. Mucokinetic drugs
Mucolytic drugs Bromhexine溴己新 Br N B NH2 Bromhexine is a synthetic derivative of the herbal active ingredient vasicine(鸭嘴花碱) used in the treatment of respiratory disorders associated with viscid or excessive mucus
Bromhexine 溴己新 • Bromhexine is a synthetic derivative of the herbal active ingredient vasicine(鸭嘴花碱) • used in the treatment of respiratory disorders associated with viscid or excessive mucus. Mucolytic drugs