Chapter 3 Pharmacokinetics 口 PK process in the body S,D Kinetic processes
Chapter 3 Pharmacokinetics PK process in the body Kinetic processes
Parta Pharmacokinetic processes D 1 Overview D 2 Transport of Drug in the Body 0 3 Pharmacokinetic Processes of the Drug 口 in the Body
Part A Pharmacokinetic Processes 1 Overview 2 Transport of Drug in the Body 3 Pharmacokinetic Processes of the Drug in the Body
1. Overview LOCUS OF ACTION TISSUE " RECEPTORS" RESERVOIRS bound free free- bound SYSTEMIC CIRCULATION ABSORPTION free drug EXCRETION bound drug metabolites BIOTRANSFORMATION
1. Overview
Drug at site of administration 1 Absorption (input) ADME Drug in plasma of the drug in 2 Distribution human body Drug in tissues + Metabollsm Metabolite(s) in tissues 4 Elimination Drug and/or metabolite(s) t in urine, feces, bile
ADME of the drug in human body
Part a Pharmacokinetic processes I 2. Transport of Drug in the Body u 2.1 Transmembrane Transport of D rus I (1)Passive Transport 口 Simple diffusion(简单扩散) 口 Filtration(滤过)
2. Transport of Drug in the Body 2.1 Transmembrane Transport of Drugs (1) Passive Transport Simple diffusion（简单扩散） Filtration（滤过） Part A Pharmacokinetic Processes