Non-Narcotic Antitussives Dextromethorphan Mechanism of action nonselective serotonin reuptake inhibitor O sigma-1 receptor agonist 口 Major metabolite dextrorphan(右啡烷) as an NMDA receptor antagonist producing effects similar to ketamine and phencyclidine(PCP,苯环利啶俗称天使尘), d Active metabolite 3-methoxymorphinan which produces local anesthetic effects in rats with a potency above dextrorphan but below dextromethorphan itself
Dextromethorphan • Mechanism of action ◆nonselective serotonin reuptake inhibitor ◆sigma-1 receptor agonist Major metabolite dextrorphan(右啡烷) as an NMDA receptor antagonist, producing effects similar to ketamine and phencyclidine (PCP,苯环利啶,俗称天使尘), Active metabolite 3-methoxymorphinan, which produces local anesthetic effects in rats with a potency above dextrorphan but below dextromethorphan itself. Non-Narcotic Antitussives
Non-Narcotic Antitussives (1)Pharmacological effects Depression of coughing center, (2)clinical uses Ipper respiratory infection and dry cough ()Adverse reaction Atropine-like side effects Contraindication: In the patients with glaucoma pregnancy (< 3 months psychotic disorders, etc
Non-Narcotic Antitussives (1)Pharmacological effects: Depression of coughing center; (2)Clinical uses: Upper respiratory infection and dry cough. (3)Adverse reaction: Atropine-like side effects. Contraindication: In the patients with glaucoma, pregnancy(< 3 months), psychotic disorders, etc
Non-Narcotic Antitussives Pentoxyverine(喷托维林,咳必清) Also known as Carbetapentane N CH CH3 (1)Pharmacological effects Depression of coughing center Local anesthetic effects, and Muscarinic antagonism
Pentoxyverine(喷托维林, 咳必清) Also known as Carbetapentane (1)Pharmacological effects: Depression of coughing center, Local anesthetic effects, and Muscarinic antagonism. Non-Narcotic Antitussives
(2)Clinical uses Upper respiratory infection Cough without sputum (3)Adverse reaction: Atropine-like side effects Uses and adverse effects are similar to dextromethorphan However, there is very little published clinical data to suggest clinical efficacy with carbetapentane leading the FDa (2007) to conclude that this drug should not be made available as an OTC treatment of cough in the USA(2007
(2)Clinical uses: Upper respiratory infection, Cough without sputum. (3)Adverse reaction: Atropine-like side effects. Uses and adverse effects are similar to dextromethorphan However, there is very little published clinical data to suggest clinical efficacy with carbetapentane leading the FDA (2007) to conclude that this drug should not be made available as an OTC treatment of cough in the USA (2007)
Non-Narcotic Antitussives Others Pharmacological effects Side effects Cloperastine a mild bronchorelaxant (氯哌斯汀) antihistaminic activity acting on the central nervous system or The respiratory cenTer Promo|ate(普 Sedative e斤fect 罗吗酯) bronchorelaxant effect Depression of coughing center Fominoben Depression of coughing center 福米诺苯) Act on respiratory center zipeprol a local anaesthetic hallucinations 齐培丙醇) mucolytic (幻觉) antihistamine properties anticholinergic properties
Others Non-Narcotic Antitussives Pharmacological effects Side effects Cloperastine （氯哌斯汀） a mild bronchorelaxant antihistaminic activity acting on the central nervous system or the respiratory center Promolate（普 罗吗酯） Sedative effect bronchorelaxant effect Depression of coughing center Fominoben （福米诺苯） Depression of coughing center Act on respiratory center Zipeprol (齐培丙醇） a local anaesthetic mucolytic antihistamine properties anticholinergic properties hallucinations (幻觉)