Massachusetts Institute of Technology yE图 Harvard medical school Brigham and women's hospital VA Boston Healthcare System 279J/3.96J/BE.441/HST522J BIOMATERIALS-TISSUE INTERACTIONS INTRODUCTION M. Spector, Ph D and I.v. Yannas, Ph D
Massachusetts In Massachusetts Institute of Technology stitute of Technology Harvard Medical School Harvard Medical School Brigham and Wo Brigham and Women’s Hospital men’s Hospital VA Boston Healthcare System VA Boston Healthcare System 2.79J/3.96J/BE.441/HST522J 2.79J/3.96J/BE.441/HST522J BIOMATERIALS BIOMATERIALS-TISSUE INTERACTIONS: TISSUE INTERACTIONS: INTRODUCTION INTRODUCTION M. Spector, Ph.D. and I.V. Yannas, Ph.D. M. Spector, Ph.D. and I.V. Yannas, Ph.D
TISSUE Tissue is a biological structure made up of cells of the same type. Cells of the same phenotype(i.e, same genes expressed) An aggregation of morphologically similar cells and associated extracellular matrix acting together to perform one or more specific functions in the body. There are four basic types of tissue: muscle, nerve, epithelia, and connective. An organ is a structure made up of 2 or more tissues
TISSUE • Tissue is a biological structure made up of cells is a biological structure made up of cells of the same type. of the same type. – – Cells of the same phenotype ( Cells of the same phenotype (i.e., same genes ., same genes expressed). expressed). – – An aggregation of morphologically similar cells and An aggregation of morphologically similar cells and associated extracellular matrix acting together to associated extracellular matrix acting together to perform one or more specific functions in the body. perform one or more specific functions in the body. – – There are four basic types of tissue: muscle, nerve, There are four basic types of tissue: muscle, nerve, epithelia, and connective. epithelia, and connective. – – An organ is a structure made up of 2 or more tissues. is a structure made up of 2 or more tissues
Articular Cartilage Extracellular latr / Cell 4 mm 10 um
Cell Extracellular Matrix 4 mm 10 µm Articular Cartilage
ENGINEERING Production of a product for human good using existing knowledge. Science is the process of acquisition of new knowledge. Technology is the means by which products are produced
ENGINEERING ENGINEERING • Production of a product for human good Production of a product for human good using existing knowledge. using existing knowledge. – Science Science is the process of acquisition of new is the process of acquisition of new knowledge. knowledge. –Technology Technology is the means by which products is the means by which products are produced. are produced
BIOMATERIALS-TISSUE INTERACTIONS Permanent versus absorbable biomaterials Roles of permanent biomaterials for the production of permanent implants versus the roles as absorbable scaffolds for tissue engineering
BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Permanent versus Absorbable Biomaterials Permanent versus Absorbable Biomaterials • Roles of permanent biomaterials for the Roles of permanent biomaterials for the production of permanent implants versus production of permanent implants versus the roles as absorbable scaffolds for tissue the roles as absorbable scaffolds for tissue engineering engineering