Fats ingested in die The emulsification, absorption and transport of diet triacylglyc 6 Fatty acids are oxidized nel or reesterified Gallbladder Myocyte or co Smal intestine ⑦ Fatty acids enter cells ① Bile salts emulsify dietary fats in the small intestine, forming Lipoprotein lipase ⑥Li activated by apoC-ll in the capillary. ② Intestinal lipases releases fatty acids and degrade triacylglycerols glycerol Intestinal ⑤ Chylomicrons move the lymphatic Apoc-Il products are taken up by the wn 6 Fatty acids and other breakdo Chylomicron intestinal mucosa and converted into triacylglycerol O Triacylglycerols are incorporated, with cholesterol and apoproteins into chylo
The emulsification, absorption and transport of diet triacylglycerol
C-C C-C C—NCH2-C HO H 0- Glycocholate HO OH Glycocholate: the main bile salts that emulsifies macroscopic fat into microscopic micelles
Glycocholate: the main bile salts that emulsifies macroscopic fat into microscopic micelles
Apoproteins A chylomicron particle B-48 C-II c-ll Phospholipids Cholesterol Triacylglycerols and cholesteryl esters
A chylomicron particle
3. Mobilization of stored triacylglycerols in adipocytes needs hormone to signal the demand The hormones epinephrine and glucagon, signaling a lack of glucose in the blood, will bind to receptors on adipocyte surface and activate the triacylglycerol lipase via phosphorylation Fatty acids released are carried to energy-demanding tissues(e.g. skeletal muscle, heart, and renal cortex) via the 62 kD monomeric serum albumin(each binding about 10 fatty acids)
3. Mobilization of stored triacylglycerols in adipocytes needs hormone to signal the demand • The hormones epinephrine and glucagon, signaling a lack of glucose in the blood, will bind to receptors on adipocyte surface and activate the triacylglycerol lipase via phosphorylation. • Fatty acids released are carried to energy-demanding tissues (e.g., skeletal muscle, heart, and renal cortex) via the 62 kD monomeric serum albumin (each binding about 10 fatty acids)
The glycerol molecule generated can be converted to glycolytic intermediate glyceraldehyde 3-phosphate by the successive action of glycerol kinase, glycerol 3-phosphate dehydrogenase, and triose phosphate somerase
• The glycerol molecule generated can be converted to glycolytic intermediate glyceraldehyde 3-phosphate by the successive action of glycerol kinase, glycerol 3-phosphate dehydrogenase, and triose phosphate isomerase