细胞科学 蔡国
细胞科学 Cell Science （13.3） 蔡国平
Apoptosis- Cells die by murder or suicide by an active process of programmed cell: death, characterized by cleavage of chromosomal DNA. chromatin condensation. and fragmentation of both the nucleus and the cell Programmed cell death playa a key role both in the maintenance of adult tissues and embryonic development In contrast to the accidental death of cells resulting from an acute injury, programmed cell death takes place by an active process and Genes responsible for both the regulation and execution of apoptosis are conserved from nematodes to humans
ApoptosisCells die by murder or suicide by an active process of programmed cell death, characterized by cleavage of chromosomal DNA, chromatin condensation, and fragmentation of both the nucleus and the cell. Programmed cell death playa a key role both in the maintenance of adult tissues and in embryonic development. In contrast to the accidental death of cells resulting from an acute injury, programmed cell death takes place by an active process and Genes responsible for both the regulation and execution of apoptosis are conserved from nematodes to humans
1.2mm ANTERIOR DORSAL Intestine nad POSTERIOR eggs 00 pharynx oocyte muscle uterus vulva hypodermis body wall VENTRAL
细胞凋亡圆 细胞凋亡( apoptosis)是Ker1972年首次提 出的。 细胞凋亡或细胞程序化死亡( programmed cell death,PCD)不同于坏死( necrosis)。 具有典型的特征,包括胞质浓缩、染色质凝集 染色体降解呈 DNA ladder、细胞膜出芽形成凋 亡小体( apoptosis bodies)。 被正常细胞或吞噬细胞清除,而不引发炎症
细胞凋亡 • 细胞凋亡（apoptosis）是Kerr于1972年首次提 出的。 • 细胞凋亡或细胞程序化死亡（programmed cell death, PCD）不同于坏死（necrosis）。 • 具有典型的特征，包括胞质浓缩、染色质凝集、 染色体降解呈DNA ladder、细胞膜出芽形成凋 亡小体（apoptosis bodies）。 • 被正常细胞或吞噬细胞清除，而不引发炎症
