Beta-adrenergic blocking agents
Beta-adrenergic blocking agents
overview Nonselective beta-blockers act at both beta1 and beta2 receptors,whereas cardioselective beta-antagonists primarily block beta-1 receptors. Do not induce postural hypotension Effective in treating angina,cardiac arrhythmias,myocardial infarction,and glaucoma
overview ◼ Nonselective beta-blockers act at both beta1 and beta2 receptors, whereas cardioselective beta-antagonists primarily block beta-1 receptors. ◼ Do not induce postural hypotension ◼ Effective in treating angina, cardiac arrhythmias, myocardial infarction, and glaucoma
propranolol Nonselective beta-antagonist Blocks both beta-1 and beta-2 receptors
propranolol ◼ Nonselective beta-antagonist ◼ Blocks both beta-1 and beta-2 receptors
Actions Cardiovascular:propranolol diminishes cardiac output,having both negative inotropic and chronotropic effects. Cardiac output,work,and oxygen consumption are decreased. Attenuating supraventricular cardiac arrhythmias
Actions ◼ Cardiovascular: propranolol diminishes cardiac output, having both negative inotropic and chronotropic effects. ◼ Cardiac output, work, and oxygen consumption are decreased. ◼ Attenuating supraventricular cardiac arrhythmias
actions Peripheral vasoconstriction:reduction of cardiac output leads to decreased blood pressure. Bronchoconstriction beta-blockers are thus contraindicted in patients with asthma Increased Na+retention Disturbances in glucose metabolism
actions ◼ Peripheral vasoconstriction: reduction of cardiac output leads to decreased blood pressure. ◼ Bronchoconstriction beta-blockers are thus contraindicted in patients with asthma ◼ Increased Na+ retention ◼ Disturbances in glucose metabolism