Section 1 Penicillins
Section 1 Penicillins
Basic structure of penicillins nucleus 6-aminopenicillanic acid (6-APA) R1—C NH A COOR B-lactamase A:Thiazolidine B:B-lactam ring
β-lactamase nucleus ： 6-aminopenicillanic acid (6-APA) B：β－lactam ring N S COOR2 O R1 C NH O B A A：Thiazolidine Basic structure of penicillins
、 Natrural penicillin 【Pharmacokinetics】 冬 intramuscular or intravenous therapy distribute to most tissues and serosa-lined cavities, low concentrations appear in cerebrospinal fluid Penicillin G is excreted by the kidneys
一、Natrural penicillin 【 Pharmacokinetics 】 ❖ intramuscular or intravenous therapy ❖ distribute to most tissues and serosa-lined cavities, low concentrations appear in cerebrospinal fluid ❖ Penicillin G is excreted by the kidneys
【Antibacterial activity】 Gram-positive coccus Gram-negative coccus Gram-positive bacilli Helicoids
【 Antibacterial activity 】 Gram-positive coccus Gram-negative coccus Gram-positive bacilli Helicoids
Gram positive coccus: staphylococci-Staphylococcus aureus Staphylococcus epidermidis streptococcus-Streptococcus hemolyticus Streptococcus pneumoniae Streptococcus viridans
Gram positive coccus: staphylococci－Staphylococcus aureus、 Staphylococcus epidermidis streptococcus－Streptococcus hemolyticus、 Streptococcus pneumoniae Streptococcus viridans