A. Androgens and antiandrogens Clinical uses (1) Replacement therapy in men hypogonadism (2)Female disorders: dysfunctional uterine bleeding endometriosis(子宫内膜异位症), advanced breast and ovarian cancers (3 Anemia: aplastic or other anemia ( largely replaced by recombinant erythropoietin (4) Infirmity(体质虚弱): anabolic steroids(同化激素) (oThers: male contraception, osteoporosis(either alone or in conjunction with estrogens. Replaced by bisphosphonates)etc
Clinical uses (1) Replacement therapy in men: hypogonadism (2)Female disorders: dysfunctional uterine bleeding, endometriosis (子宫内膜异位症), advanced breast and ovarian cancers (3) Anemia: aplastic or other anemia (largely replaced by recombinant erythropoietin ) (4) Infirmity (体质虚弱): anabolic steroids (同化激素) (5) Others: male contraception, osteoporosis(either alone or in conjunction with estrogens. Replaced by bisphosphonates) etc. A. Androgens and antiandrogens
A. Androgens and antiandrogens Adverse effects due largely to their masculinizing actions and are most noticeable in women and prepubertal children (1) Sex dysfunction: virilisation in female (hirsutism acne amenorrhea, clitoral enlargement, and deepening of the voice, testosterone> 200-300 mg of per month) o increased libido in male (2) Hepatic toxicity occurs early in the course of treatment, the degree is proportionate to the dose bilirubin levels t
Adverse effects - due largely to their masculinizing actions and are most noticeable in women and prepubertal children. (1) Sex dysfunction: • virilisation in female(hirsutism, acne, amenorrhea, clitoral enlargement, and deepening of the voice, testosterone> 200–300 mg of per month) • increased libido in male (2) Hepatic toxicity • occurs early in the course of treatment, the degree is proportionate to the dose. bilirubin levels ↑ A. Androgens and antiandrogens
A. Androgens and antiandrogens Contraindications 1. pregnant women, infants and young children (somatotropin is more appropriate to produce a growth spurt) 2. male patients with carcinoma of the prostate or breast. 3. renal or cardiac disease predisposed to edema Caution: Several cases of hepatocellular carcinoma have been reported in patients with aplastic anemia treated with androgen anabolic therapy. Erythropoietin and colony- stimulating factors should be used instead
A. Androgens and antiandrogens Contraindications 1. pregnant women, infants and young children (somatotropin is more appropriate to produce a growth spurt). 2. male patients with carcinoma of the prostate or breast. 3. renal or cardiac disease predisposed to edema Caution: Several cases of hepatocellular carcinoma have been reported in patients with aplastic anemia treated with androgen anabolic therapy. Erythropoietin and colonystimulating factors should be used instead
A. Androgens and antiandrogens Classic anabolic hormones 1. Growth hormone 2. IGF1 and other insulin-like growth factors 3. Insulin 4. Testosterone and analogs 5. Estradiol
A. Androgens and antiandrogens Classic anabolic hormones 1. Growth hormone 2. IGF1 and other insulin-like growth factors 3. Insulin 4. Testosterone and analogs 5. Estradiol