Z【Clinical uses】 1.Gram-positive coccus infection staphylococci:bouton (boil) streptococci:pharyngitis,febris rubra streptococcus pneumoniae:pneumonia genuina 2.Corynebacterium diphtheriae 3.Chlamydial infections urethral,endocervical,rectal,epididymal,urogenital 4.Mycoplasmal pneumonia 5.Legionella pneumonia
【Clinical uses】 1. Gram-positive coccus infection staphylococci: bouton (boil) streptococci: pharyngitis, febris rubra streptococcus pneumoniae: pneumonia genuina 2. Corynebacterium diphtheriae 3. Chlamydial infections urethral, endocervical, rectal, epididymal, urogenital 4. Mycoplasmal pneumonia 5. Legionella pneumonia
【Adverse effect】 1.Gastrointestinal effects Anorexia,nausea,vomiting,and diarrhea 2.Cholestatic jaundice estolate form of erythromycin 3.Ototoxicity Transient deafness Contraindications:hepatic dysfunction
【Adverse effect】 1. Gastrointestinal effects Anorexia, nausea, vomiting, and diarrhea 2. Cholestatic jaundice estolate form of erythromycin 3. Ototoxicity Transient deafness Contraindications: hepatic dysfunction
【Drug resistance】 1.Reduced permeahility af tha all mm methylation of an adenine of the or active efflux 23S bacterial ribosomal RNA 2.Modification of the roma binding site 3.Production of esterases that hydrolyze macrolides
【Drug resistance】 1. Reduced permeability of the cell membrane or active efflux 2. Modification of the ribosomal binding site 3. Production of esterases that hydrolyze macrolides methylation of an adenine of the 23S bacterial ribosomal RNA
二、Clarithromycin 1.Its activity against Chlamydia,Legionella and Ureaplasma is higher than that of erythromycin. 2.It has lower frequency of gastrointestinal intolerance
二、Clarithromycin 1. Its activity against Chlamydia, Legionella and Ureaplasma is higher than that of erythromycin. 2. It has lower frequency of gastrointestinal intolerance
三、Azithromycin 1.Azithromycin is more active against Haemophilus influenzae and Chlamydia than erythromycin 2.It is less active against streptococci and staphylococci 3.It is now used for urethritis caused by Chlamydia trachomatis. 4.It is rapidly absorbed and well tolerated orally
三、Azithromycin 1. Azithromycin is more active against Haemophilus influenzae and Chlamydia than erythromycin 2. It is less active against streptococci and staphylococci 3. It is now used for urethritis caused by Chlamydia trachomatis. 4. It is rapidly absorbed and well tolerated orally