Chapter 37 Macrolides Lincomycins Polypeptide antibiotics
Macrolides Lincomycins Polypeptide antibiotics Chapter 37
Macrolides Erythromycin Clarithromycin Azithromycin
Macrolides Erythromycin Clarithromycin Azithromycin
Erythromycin (Pharmacokinetics 1.Erythromycin base is destroyed by gastric acid 2.It distributes well to all body fluids including prostatic fluid,but it does not enter the cerebrospinal fluid (CSF) 3.Erythromycin is extensively metabolized and is excreted in the bile,and only 5%is excreted in the urine
一、Erythromycin 【Pharmacokinetics】 1. Erythromycin base is destroyed by gastric acid 2. It distributes well to all body fluids including prostatic fluid ,but it does not enter the cerebrospinal fluid (CSF) 3. Erythromycin is extensively metabolized and is excreted in the bile, and only 5% is excreted in the urine
【Antibacterial activity】 1.Erythromycin is bacteriostatic 2.It is effective against gram-positive organisms 3.It is active against some gram-negative organisms 4.Mycoplasma,Chlamydozoan,Legionella and campylobacteria are susceptible
【Antibacterial activity 】 1. Erythromycin is bacteriostatic 2. It is effective against gram-positive organisms 3. It is active against some gram-negative organisms 4. Mycoplasma, Chlamydozoan, Legionella and campylobacteria are susceptible
Mechanism of action】 Inhibit protein synthesis Erythromycin(50S) translocase
P A P A P A translocase Inhibit protein synthesis 【Mechanism of action】