GlucocorticoidsClassification accordingto duration ofaction>Short-actingglucocorticoids（<12hours)--cortisone,hydrocortisone>lIntermediate-actingglucocorticoids(12-36hours)-prednisone,prednisolone>Long-actingglucocorticoids(>36hours)dexamethasone,betamethasone
Glucocorticoids Classification according to duration of action ➢ Short-acting glucocorticoids ( < 12 hours) - cortisone, hydrocortisone ➢ Intermediate-acting glucocorticoids (12~36 hours) - prednisone, prednisolone ➢ Long-acting glucocorticoids ( > 36 hours) - dexamethasone, betamethasone
GlucocorticoidsPhysiologic effectsTheglucocorticoidshavewidespreadeffectsbecause they influence the function of most cells inthe body.Physiologic secretion of them have effectson carbohydrate,proteinandlipid metabolism as wellasmaintance offluid-electrolytebalance.Attherapeutic doses,especiallylarge amounts orlong term are administered for therapeutic purpose,the same effects are responsible for some adverseeffects
Glucocorticoids Physiologic effects The glucocorticoids have widespread effects because they influence the function of most cells in the body. Physiologic secretion of them have effects on carbohydrate, protein and lipid metabolism as well as maintance of fluid-electrolyte balance. At therapeutic doses, especially large amounts or long term are administered for therapeutic purpose, the same effects are responsible for some adverse effects