Agents Affecting theThyroid Gland
Agents Affecting the Thyroid Gland
Thyroid Hormones (TH)Thyroid gland is one of the most importantendocrine glands.Thefolliclecellscansynthesize and secrete thyroid hormones thatregulate the growth and metabolism of body
Thyroid Hormones (TH) Thyroid gland is one of the most important endocrine glands. The follicle cells can synthesize and secrete thyroid hormones that regulate the growth and metabolism of body
Thyroid GlandAnterior View@Novartis
Thyroid Histology
Thyroid Histology
Synthesis of Thyroid HormonesIodide trapping. Oxidation of iodide by thyroidal peroxidase to iodine· Iodinated tyrosine residues within the thyroglobulinmolecule to form monoiodotyrosine(MIT)anddiodotyrosine (DIT)Coupled by peroxidase:MIT+DIT-→triiodothyronine(T3)DIT+DIT-→thyroxine(T4)
Synthesis of Thyroid Hormones • Iodide trapping • Oxidation of iodide by thyroidal peroxidase to iodine • Iodinated tyrosine residues within the thyroglobulin molecule to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) • Coupled by peroxidase: MIT+DIT→triiodothyronine(T3 ) DIT+DIT→thyroxine(T4 )