Macrolides 大环内酯类Lincomycin 林肯霉素Clindamycin氯林可霉素
Macrolides 大环内酯类 Lincomycin 林肯霉素 Clindamycin 氯林可霉素
1. Overview2.Macrolides 大环内酯类3. Lincomycin 林肯霉素4.Clindamycin 氯林可霉素
1. Overview 2. Macrolides 大环内酯类 3. Lincomycin 林肯霉素 4. Clindamycin 氯林可霉素
1. Overviewbacterialeucaryotic70S80Sribosomeribosomesubunits30S40S50S60SS=Svedbergunitsof sedimentationRibosomes 核糖体 are made ofRNA and proteinsatomicTheytranslate informationfromstructureofthe50smessengerRNAintonewproteinssubunitTheribosomesofbacterialandeukaryotorganismsshowdifferences
1. Overview Ribosomes 核糖体 are made of RNA and proteins They translate information from messenger RNA into new proteins The ribosomes of bacterial and eukaryot organisms show differences
Protein SynthesisaminoAAribosomeacidAAAAtransferantiRNAAAcodon(tRNA)anticodoncodoncodonPAmessengerRNA(mRNA)Tetracyclines四环素类EcompetewithtRNAfortheAsite
Protein Synthesis Tetracyclines 四环素类 compete with tRNA for the A site
bindingoftRNAAAattheAsiteaccordingtotheAAcodon-anticodonrecognitionAAAAthe P sitecontains theprotein informationantianticodoncodoncodoncodonPAAminoglycosides氨基糖贰类cause anabnormal codon-anticodon recognition by binding to the 3oS subunit
Aminoglycosides 氨基糖甙类 cause an abnormal codonanticodon recognition by binding to the 30S subunit