FOLATEANTAGONISTS
FOLATE ANTAGONISTS
SyntheticAntimicrobial DrugsSulfonamides Trimethoprim （TMP)
Synthetic Antimicrobial Drugs • Sulfonamides • Trimethoprim ( TMP )
OVERVIEWFolic acid functions as a coenzyme in thetransfer of one-carbonunits required forthesynthesis of thymidine, purines, and some aminoacids and consists of three components: a pteridinemoiety,PABA, and glutamateCOOH-CH2-CH2B---NH-CHH21NE-COOHNOHPteridinePABAGlutamate
I OVERVIEW Folic acid functions as a coenzyme in the transfer of one-carbon units required for the synthesis of thymidine, purines, and some amino acids and consists of three components: a pteridine moiety, PABA, and glutamate
Susceptible bacteria are those that need PABAbecause they are incapable of utilizing folic aciddirectly.Human cells utilize exogenous folic acidexclusively.ThelackofPABAdonotaffectthem
Susceptible bacteria are those that need PABA because they are incapable of utilizing folic acid directly. Human cells utilize exogenous folic acid exclusively. The lack of PABA do not affect them
SulfonamidesThe classification of sulfonamides· Drugs used in general infections:SIZ-SulfisoxazoleSD-SulfadiazineSMZ-Sulfamethoxazole.Drugs used in enteric infections:SASP- Salazosulfapyridine· Drugs used in local infections:SA-Sulfacetamide SodiumSML- SulfamylonSD-Ag-Sulfadiazine Silver
Sulfonamides The classification of sulfonamides • Drugs used in general infections: - Sulfisoxazole SIZ - Sulfadiazine SD - Sulfamethoxazole SMZ • Drugs used in enteric infections: - Salazosulfapyridine SASP • Drugs used in local infections: - Sulfacetamide Sodium SA - Sulfamylon SML - Sulfadiazine Silver SD-Ag