Antidiabetic Drugs
Antidiabetic Drugs
InsulinInsulin is a small protein containing51 amino acids and is secreted from β cellsof pancreas.The main factor controlling thesynthesis and secretion of insulin is theblood glucose concen-tration
Insulin Insulin is a small protein containing 51 amino acids and is secreted from β cells of pancreas. The main factor controlling the synthesis and secretion of insulin is the blood glucose concen-tration
Pharmacological Effects.Carbohydrate metabolism·Increase glucose utilization·Decrease glucose synthesisFatmetabolismIncreaselipogenesis·Decease lipolysisProteinmetabolismIncreaseproteinsynthesis·Decrease protein breakdown
Pharmacological Effects • Carbohydrate metabolism • Increase glucose utilization • Decrease glucose synthesis • Fat metabolism • Increase lipogenesis • Decease lipolysis • Protein metabolism • Increase protein synthesis • Decrease protein breakdown
PharmacologicalEffects.Potassiumtransportation.PromoteKtinfluxofcell·Growth-promotingactionPromote protein,fatand ribonucleoside synthesis
Pharmacological Effects • Potassium transportation • Promote K+ influx of cell • Growth-promoting action • Promote protein, fat and ribonucleoside synthesis
PharmacokineticsThe liver and kidney are the principalsites of insulin uptake and degradationEach is capable of destroying 40% of theinsulin produced per day.Some of thepharmacokinetic properties of differentcommercially available insulin preparationaredepicted inTable31-2
Pharmacokinetics • The liver and kidney are the principal sites of insulin uptake and degradation. Each is capable of destroying 40% of the insulin produced per day. Some of the pharmacokinetic properties of different commercially available insulin preparation are depicted in Table 31-2