NonsteroidalAnti-inflammatoryDrugs,Disease-Modifying Antirheumatic Drugs,Nonopioid Analgesics,and Drugs Used inGout
Nonsteroidal Anti-inflammatory Drugs, Disease-ModifyingAntirheumatic Drugs, Nonopioid Analgesics,and Drugs Used in Gout
theinflammatory responseWhat is Concepts ofinflammation?Inflammation describes the changesinseenresponse to tissue injury or insultThe hallmark ofinflammatory are:rednessswellingpainloss of function
the inflammatory response What is Concepts of inflammation? Inflammation describes the changes seen in response to tissue injury or insult. The hallmark of inflammatory are: redness swelling pain loss of function
inflammation is commonly divided intothreephases.acute inflammationthe immuneresponsechronic inflammationThe main cells and autacoids in inflammation are.neutrophil leucocytesmacrophageshistaminebradykininneuropeptides(substance-p,calcitonin,)cytokines(interleukins)the arachidonic acid metabolites(eicosanoids)
inflammation is commonly divided into three phases: acute inflammation the immune response chronic inflammation The main cells and autacoids in inflammation are: neutrophil leucocytes macrophages histamine bradykinin neuropeptides(substance-p, calcitonin, ) cytokines( interleukins) the arachidonic acid metabolites(eicosanoids)
Arachidonic acid metabolites: the eicosanoidsThe eicosanoids are of special importanceBiosyntheticpathway oftheeicosanoidsPhospholipids is mobilized by the enzyme PLA2arachidonic acid is metabolized, various eicosanoids aresynthesized.Theofarachidonatecyclooxygenasepathwayandmetabolism produces prostaglandins, thromboxanetheByproduceprostacyclintolipoxygenaseleukotrienes
Arachidonic acid metabolites: the eicosanoids The eicosanoids are of special importance Biosynthetic pathway of the eicosanoids Phospholipids is mobilized by the enzyme PLA2 arachidonic acid is metabolized, various eicosanoids are synthesized. The cyclooxygenase pathway of arachidonate metabolism produces prostaglandins, thromboxane and prostacyclin By lipoxygenase to produce the leukotrienes
Biosynthetic pathway of the eicosanoidMembranephospholipidPLA2|glucocorlicoidArachidonicacid-NSAIDSCOX+5-lipoxygenaseCyclicendoperoxides5-HPETEThromboxaneProstacyclin synthetaseLTA4LTB4synthetaseLTCPGE2PGF2TXA2PGl2TD→LTEA
Biosynthetic pathway of the eicosanoid LTA4 Membrane phospholipid Arachidonic acid PLA2 COX 5-HPETE Cyclic endoperoxides PGI2 PGE2 PGF2 TXA2 glucocorlicoid LTB4 LTD4 LTC4 LTE4 NSAIDS 5-lipoxygenase