AdrenocorticalHormones
Adrenocortical Hormones
IntroductionsteroidsAdrenocorticalhormonesareadrenal cortex.The secretionsecreted fromisofcontrolledby the pituitaryreleasecorticotropin (ACTH) and renin-angiotensin-system (RAS)
Introduction Adrenocortical hormones are steroids secreted from adrenal cortex. The secretion is controlled by the pituitary release of corticotropin (ACTH) and renin-angiotensinsystem (RAS)
ClassificationGlucocorticoids(fromzonafasciculata)-cortisone,hydrocortisoneMineralocorticoids(fromzonaglomerulosa)--aldosterone,desoxycorticosteroneSexhormones (fromzona reticularis)福androgen
Classification ➢ Glucocorticoids (from zona fasciculata) - cortisone, hydrocortisone ➢ Mineralocorticoids (from zona glomerulosa) - aldosterone, desoxycorticosterone ➢ Sex hormones (from zona reticularis) - androgen
HypothalamusstressCorticotropinreleasingfactorAnteriorpituitaryCorticotropin(ACTH)zonaAidosteroneglomerulosaZonaCortisolfasciculataZonaAndrogensreticularisAdrenalmedulla
SecretedRateandBloodConcentrationof TypicalAdrenocorticalHormonesAldosteroneHydrocortisone10 mg/d0.125 mg/dSecretedrate at normal conditionPeripheral plasma concentration8AM16 μg/100ml0.1 μg/100ml4 PM4 μg/100ml0.1μg/100ml
Secreted Rate and Blood Concentration of Typical Adrenocortical Hormones Hydrocortisone Aldosterone Secreted rate at normal condition 10 mg/d 0.125 mg/d Peripheral plasma concentration 8 AM 16 μg/100ml 0.1 μg/100ml 4 PM 4 μg/100ml 0.1 μg/100ml