Intracellular bacteria Macrophage or neutrophil Lysozome Bacteria Phagosome Phagolysosomes No fusion Fusion Enter cytoplasm
Intracellular bacteria No fusion Lysozome Phagosome Fusion Enter cytoplasm Bacteria Macrophage or neutrophil Phagolysosomes 6
Intracellular bacteria Listeria cytoplasm Shigella Endosomes Phagolysosomes Salmonella Legionella Mycobacteria Chlamydia lysosomes Phagosome
Endosomes Phagosomes lysosomes Phagolysosomes Legionella Chlamydia Listeria Shigella Sammonella Mycobacteria Intracellular bacteria cytoplasm 7
Balance between Infection and Immunity Pathogen Host infection immunity Virulence VS Host-resistance -immunity Bolus of infection x virulence Disease s immunity
Pathogen infection Host immunity Bolus of infection x virulence immunity Disease = Host-resistance -immunity Balance between Infection and Immunity Virulence vs
Protective Immunity To Bacteria Defense against microbes is mediated by Innate immunity and acquired immunity Humoral immunity(antibodies) Through both Cell mediated immunity( CM
Protective Immunity To Bacteria Defense against microbes is mediated by: Innate immunity and acquired immunity Humoral immunity (antibodies) Through both Cell mediated immunity (CMI)
Time Table of immune responses Against re-infection Innate immunigy Recognition by Removal of immediate: Infection reformed 0-4 hours) nonspecific effectors infectious agent Early induced T Recognition of Inflammation Infection microbial-associated,> recruitment and Removal of response activation of (early: 4-96 hours) molecular patter infectious agent effector cells Adaptive immune Transport of Recognition Clonal expansion Removal response Infection tigen to by naive and differentiation of (ate: >96 hours) ymphoid organs B and T cells to effector cells infectious agent Figure 2-1 Immunobiology, 6/e ( Garland Science 2005)
Figure 2-1 Time Table of immune responses Against re-infection?