Normal human microbiota Pathogenesis of Bacterial Infection DiQu(瞿涤) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学基础医学院 医学分子病毒学教育部卫生部重点实验室 Chapter 10 Chapter 9
Normal Human Microbiota Pathogenesis of Bacterial Infection Shibo Jiang (姜世勃) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学上海医学院分子病毒学教育部/卫生部重点实验室 Di Qu (瞿涤) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学基础医学院 医学分子病毒学教育部/卫生部重点实验室 Chapter 10 Chapter 9
Key Words Pathogen Opportunistic pathogen Adhesion Normal microbiota Penetration Pathogenicity Invasiveness/spread Extra/intra cellular bacteria Virulence Exotoxin Opportunistic infection Nosocomial infection Toxoid Koch's postulates Endotoxin Carrier Transmission Compromised host Outbreak, Epidemic, Pandemic Bacterial biofilm
Key Words Adhesion Penetration Invasiveness/spread Extra/intra cellular bacteria Exotoxin Toxoid Endotoxin Carrier Compromised host Bacterial biofilm Pathogen Opportunistic pathogen Normal microbiota Pathogenicity Virulence Opportunistic infection Nosocomial infection Koch’s postulates Transmission Outbreak, Epidemic, Pandemic
Outline of the lecture Normal microbiota =normal flora Y Opportunistic infections Koch's postulates v Virulence of bacteria Invasive oxins -endotoxin exotoxin v Bacterial biofilms v Modes of infectious disease transmission Infections v Control of nosocomial infection
Outline of the lecture Normal microbiota =Normal flora Opportunistic infections Koch's postulates Virulence of bacteria Invasive Toxins – endotoxin exotoxin Bacterial biofilms Modes of infectious disease transmission Infections Control of Nosocomial Infection
Microbes and humans At lest two questions here Very few microbes are How to identify always pathogenic a pathogen? Many microbes are potentially pathogenic Under what condition? Opportunistic Most microbes are infection never pathogenic ()
Microbes and humans Very few microbes are always pathogenic Many microbes are potentially pathogenic Most microbes are never pathogenic Under what condition? -Opportunistic infection How to identify a pathogen? At lest two questions here
Microbes and human Normal flora =Normal microbiota(beneficial or ignored) GI track, skin, upper respiratory track Opportunistic bacteria(when host with underline problem) Pseudomonas aeruginosa: cystic fibrosis/burn Kaposis sarcoma(herpesvirus): AIDS E coll, Staphylococcus Virulent bacteria (actively cause disease) Mobile genetic elements pathogenic islands
Microbes and Human Normal flora =Normal microbiota (beneficial or ignored): GI track, skin, upper respiratory track… Opportunistic bacteria (when host with underline problem): Pseudomonas aeruginosa: cystic fibrosis/ burn Kaposi’s sarcoma (herpesvirus): AIDS E.coli，Staphylococcus Virulent bacteria (actively cause disease): Mobile genetic elements pathogenic islands