Antibiotic and drug resistance Laboratory Diagnosis of Infection DiQu(瞿涤) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学基础医学院 医学分子病毒学教育部卫生部重点实验室 Chapter 28
Antibiotic and drug resistance Laboratory Diagnosis of Infection Shibo Jiang (姜世勃) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学上海医学院分子病毒学教育部/卫生部重点实验室 Di Qu (瞿涤) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学基础医学院 医学分子病毒学教育部/卫生部重点实验室 Chapter 28
Key Words Antibiotic Selective toxicity Penicillins Bactericidal Beta lactam Bacteriostatic Penicillinase/ beta lactamase Drug resistance Inhibitor of beta lactamase
Key Words Antibiotic Selective toxicity Penicillins Bactericidal Beta lactam Bacteriostatic Penicillinase/ beta lactamase Drug resistance Inhibitor of beta lactamase 2
Terms antibiotics related Machanisim of Antibiotics Inhibit cell wall synthesis Inhibit protein synthesis nhibit nucleic acid synthesis Inhibit metabolism Antimicrobial Drug Resistance Mechanisms Genetics of antibiotics resistance Intrinsic resistant acquired resistant -mutation transposable: R plasmid, Tn integron Combat Antimicrobial Resistance
Terms antibiotics related Machanisim of Antibiotics Inhibit cell wall synthesis Inhibit protein synthesis Inhibit nucleic acid synthesis Inhibit metabolism Antimicrobial Drug Resistance Mechanisms Genetics of antibiotics resistance Intrinsic resistant acquired resistant -mutation -transposable: R plasmid, Tn & integron Combat Antimicrobial Resistance 3
Antibiotics: a compound or substance that kills or suppresses the growth of bacteria/or fungi Selectivity toxicity A drug that kills harmful microbes without damaging the host Selectively toxic for bacteria destroy structures present in bacteria, not present in host Minimize harm to patient less or no toxic to patient
Selectivity toxicity A drug that kills harmful microbes without damaging the host Selectively toxic for bacteria -destroy structures present in bacteria, not present in host Minimize harm to patient - less or no toxic to patient Antibiotics: a compound or substance that kills or suppresses the growth of bacteria/or fungi
Bacteriostatic vs Bactericidal Bacteriostatic inhibit bacteria growth without death allows for natural immunity to deal with the microbe (antibodies, phagocytosis etc) Bactericidal Kill bacteria may lead to release of toxins and microbial contents leading to subsequent illness and inflammatory responses
Bacteriostatic vs Bactericidal Bacteriostatic -inhibit bacteria growth without death -allows for natural immunity to deal with the microbe (antibodies, phagocytosis etc) Bactericidal - Kill bacteria - may lead to release of toxins and microbial contents leading to subsequent illness and inflammatory responses