Virus Pathogenesis Antiviral Defenses Youhua xie(谢幼华) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University 复旦大学上海医学院 分子病毒学教育部/卫生部重点实验室 yhxie@fudan.edu.cn
Virus Pathogenesis & Antiviral Defenses Virus Pathogenesis & Antiviral Defenses Youhua Xie Youhua Xie (谢幼华 ) MOH&MOE Key Lab of Medical Molecular Virology Sh h i M di l C ll F d U i it Shang h ai M edical C ollege, F u dan U niversit y 复旦大学上海医学院 分子病毒学教育部 /卫生部重点实验室 yhxie@fudan.edu.cn
Only A Few Human Viruses Are Pathogenic o Many viruses on the earth do not infect humans Infections with most of human viruses take place and proceed unnoticed, producing no diseases Non-pathogenic Controlled by human antiviral defenses
Only A Few Human Viruses Are Pathogenic z Many viruses Many viruses on the earth do on the earth do not infect not infect humans z Infections with most of human viruses take place and proceed unnoticed, p g roducin g no diseases ¾ Non-pathogenic ¾ Controlled by human antiviral defenses Controlled by human antiviral defenses
Viral Pathogenesis The process of producing diseases by viral infections The factors that determine the development of viral disease in the host involve complex and dynamic interactions between the virus and the susceptible host o Disease severities are varied, ranging from very mild to fatal depending on the role of both viral and host factors in influencing viral infection and disease progression
Viral Pathogenesis z The process of di pro ucing diseases by vi l i f ti iral infections z The factors that determine the development of viral disease in the host involve complex and dynamic interactions between the host involve complex and dynamic interactions between the virus and the susceptible host z Disease severities are varied ranging from very mild Disease severities are varied, ranging from very mild to fatal, depending on the role of both viral and host factors in influencing viral infection and disease progression
Viral Epidemiology Study the distribution of determinants of disease in human populations Endemic (infections present at fairly low but constant level) Epidemic(infections occur greater than usually found in the population) e Pandemic(infections are spread worldwide)
Viral Epidemiology z Study the distribution istribution of determinants rminants of disease in human populations z Endemic (infections present at fairly low but constant level) z Epidemic (infections occur greater than usually found in the population) z Pandemic (infections are spread worldwide)
Viral Pathogenesis iral pathogenesis can be divided into several stages aspects Transmission and entry of the virus into the host Spread in the host (systemic or localized infections) Tropism Virulence Patterns of viral infection and disease Host factors host defense
Viral Pathogenesis z Viral pathogenesis can be divided into several stages & aspects ¾ Transmission and entry of the virus into the host ¾ Sp (y ) read in the host (systemic or localized infections) ¾ Tropism ¾ Virulence ¾ Patterns of viral infection and disease ¾ Host factors & host defense