-DNA DNA- Nucleus 5 Primary Processing transcript mRNA- Cytosol mRNA Transport Ribosome Ribosome- 99 Nascent Nascent- protein PROKARYOTE protein EUKARYOTE The process of gene expression in prokaryotes and eukaryotes 2025/5/15 11
2025/5/15 11 The process of gene expression in prokaryotes and eukaryotes
Section 2 Gene regulation in prokaryotes 2025/5/15 12
2025/5/15 12 Section 2 Gene regulation in prokaryotes
2-1 Theory of operon(操纵子学说)： In 1961,Jacob and Monod put forward the theory of operon for the first time after studying on the regulation of lactose metabolism in E.coli. The winners of Nobel Prize in Physiology or Medicine in 1965. 2025/5/15 13
2025/5/15 13 2-1 Theory of operon（操纵子学说）： ◼ In 1961, Jacob and Monod put forward the theory of operon for the first time after studying on the regulation of lactose metabolism in E. coli. ◼ The winners of Nobel Prize in Physiology or Medicine in 1965
.Regulation of a gene usually occurs through transcriptional control. Operon theory states that genes that function together are often regulated together and are known as an operon. lac Jacob and Monod Repressor 14
2025/5/15 14 Jacob and Monod •Regulation of a gene usually occurs through transcriptional control. Operon theory states that genes that function together are often regulated together and are known as an operon
What's the operon? A unit of prokaryotic gene expression and regulation which typically includes promoter, operator gene,one or more structural genes, which is controlled as a unit to produce messenger RNA(mRNA),and regulator gene whose products recognize and control the operator gene. 操纵子：是指细菌基因表达和调节的基本单位，其中含有启动子、操纵基因及 其所控制的一组功能上相关的结构基因，以及调节基因。操纵基因受调节基因 表达产物的控制。 2025/5/15 15
2025/5/15 15 What’s the operon? A unit of prokaryotic gene expression and regulation which typically includes promoter, operator gene, one or more structural genes, which is controlled as a unit to produce messenger RNA (mRNA), and regulator gene whose products recognize and control the operator gene. 操纵子：是指细菌基因表达和调节的基本单位，其中含有启动子、操纵基因及 其所控制的一组功能上相关的结构基因，以及调节基因。操纵基因受调节基因 表达产物的控制