AAtranspeptidationAAAAAAantianticodoncodoncodoncodonPAChloramphenicol 氯霉素 inhibits transpeptidation
Chloramphenicol 氯霉素 inhibits transpeptidation
translocationAAAAAAAAanticodonanticodoncodoncodoncodonA4Macrolides大环内酯类Einhibits translocation
Macrolides 大环内酯类 inhibits translocation
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2.Macrolides 大环内酯类Erythromycin,discovered in 1952,isproducedbyaStreptomyces bacterium. Clarithromycin and azithromycin aresemisynthetic derivatives.Like penicillin G, they are essentially active against Gram(+)organisms.Differences include:.someactivity against Mycoplasma and Chlamydia.a lesser risk of allergic reactions·abettersafetyduringpregnancy·no use against meningitidis
2. Macrolides 大环内酯类 Erythromycin, discovered in 1952, is produced by a Streptomyces bacterium. Clarithromycin and azithromycin are semisynthetic derivatives. Like penicillin G, they are essentially active against Gram(+) organisms. Differences include: •some activity against Mycoplasma and Chlamydia •a lesser risk of allergic reactions •a better safety during pregnancy •no use against meningitidis
Structures of Major MacrolidesMHCH,CHN(CHa)2OHH,CHOKCHN(CH,2HOH.CoHOOH1414H,COCHSCHHCHHOCHH,CCHSOHCHOHH.COCH,clarithromycin克拉霉素红霉素erythromycinMacrolides containalargelactoneH40N(CH)2ring.Clarithromycin andHOHCazithromycindiffer onlyslightlyHOfromerythromycin.ThosesmallOCHsCHdifferencesbroadenthedistributionCHsOHand spectrum.Thegain isessentially in pharmacokinetics.阿齐霉素azithromycin
Structures of Major Macrolides 红霉素 阿齐霉素 克拉霉素 Macrolides contain a large lactone ring. Clarithromycin and azithromycin differ only slightly from erythromycin. Those small differences broaden the distribution and spectrum. The gain is essentially in pharmacokinetics