第十四章 神经营养因子 Neurotrophic Factor NTF-神奇的神经元营养品
第十四章 神经营养因子 Neurotrophic Factor NTF-神奇的神经元营养品
简介 在发育的过程中，一个神经元怎样找到它的靶组织？ 半个世纪前，发现细胞外的信号能促进神经细胞的 生长、分化。 ·1948年，Bueker首次提出存在NGF。 Rita Levi-Montalcini和Victor Hamburger也证明了 存在着促进这些神经节中神经元生长的可溶性物质。 Levi-Montalcini将一小片含有感觉神经元或交感神 经元的组织放入培养皿中，发现来自肌擅的细胞非 常剧烈地刺激神经突起(neuritic)向外生长
简 介 • 半个世纪前，发现细胞外的信号能促进神经细胞的 生长、分化。 • 1948年，Bueker 首次提出存在NGF。 • Rita Levi-Montalcini和Victor Hamburger也证明了 存在着促进这些神经节中神经元生长的可溶性物质。 • Levi-Montalcini将一小片含有感觉神经元或交感神 经元的组织放入培养皿中，发现来自肌瘤的细胞非 常剧烈地刺激神经突起(neuritic) 向外生长 。 在发育的过程中，一个神经元怎样找到它的靶组织？
(A) (B) Limb bud ablation Spinal cord section 1 week later Ventral horn Missing Normal limb 1934:Victor Hamburger discovered that removal of a limb bud resulted in reduced numbers of sensory and motor neurons in the spinal cord 2001 Sinauer Associates,Inc
3 1934: Victor Hamburger discovered that removal of a limb bud resulted in reduced numbers of sensory and motor neurons in the spinal cord
Based on his limb-bud experiments,V.Hamburger hypothesized that the targets of innervating neurons provide signals that recruit undifferentiated cells to develop into sensory or motor neurons. proposed that target derived signals Taget source ol tieurors ipproach target neurotrohic factor ng neurons.In 1949,Hamburger and bud experiments and found that their aypothesis. 49)J.Exp.Zool.111:457-502. Limited suply of Deceneratng nearon neuotrothic factor 4
4 Based on his limb-bud experiments, V. Hamburger hypothesized that the targets of innervating neurons provide signals that recruit undifferentiated cells to develop into sensory or motor neurons. In 1942, Levi-Montalcini and Levi proposed that target derived signals maintain survival of differentiating neurons. In 1949, Hamburger and Levi-Montalcini repeated the limb bud experiments and found that their results supported the neurotrophic hypothesis. Hamburger, V. and Levi-Montalcini, R. (1949) J. Exp. Zool. 111: 457-502
(C) (D) Transplantation of Effect of Removing or Augmenting Neural supernumerary Targets on the Survival of Related Neurons limb bud Spinal cord section 1 week later Extra Normal limb 1949:Victor Hamburger showed that transplantation of a supernumerary limb resulted in increased numbers of sensory and motor neurons in the spinal cord. 9 2001 Sinauer Associates,Inc
5 1949: Victor Hamburger showed that transplantation of a supernumerary limb resulted in increased numbers of sensory and motor neurons in the spinal cord. Effect of Removing or Augmenting Neural Targets on the Survival of Related Neurons