Classification of Antianginal drugs accordingto mechanism of action1. Nitrates and nitritesnitroglycerintypical medicine:2. B-adrenergic receptor blockerstypical medicine:propranolol3. Ca++ channel blockerstypical medicine:verapamil diltiazem
Classification of Antianginal drugs according to mechanism of action 1. Nitrates and nitrites typical medicine: nitroglycerin 2. ß-adrenergic receptor blockers typical medicine: propranolol 3. Ca++ channel blockers typical medicine: verapamil diltiazem
.Other drugs for treatment (or we sayprevention) of angina pectoris are:anticoagulantdrugsthrombolyticsagentsantiplateletagents
•Other drugs for treatment (or we say prevention) of angina pectoris are: anticoagulant drugs thrombolytics agents antiplatelet agents
Nitrates and Nitrites福CH 2O-NO2O—NO2CHO-NO2CHCHCH-CHCHCHCH2—0—NO2ONO2Nitroglycerin福Isosorbide Dinitrate00- NO2CH一CH一CHCHCHCHIsosorbide -5-MononitrateOH
CH 2 CH2 CH O NO2 O NO2 O NO2 Nitroglycerin CH2 CH CH CH CH CH2 O NO 2 O NO 2 O O CH2 CH CH CH CH CH2 O NO2 O H O O Isosorbide Dinitrate Isosorbide -5-Mononitrate I. Nitrates and Nitrites
Nitroglycerin【Pharmacokineticsthe drug is not administrated by oral route.Because of Significant first-pass effects.幻灯片 9It is usually given sublingually, may be giveneither topically_or inhalation ally or buccally.幻灯片 1lIf sublingual route, the bioavailability (F) is 80%the onset of action is 1 to 2 minutes, and the durationof action is 20 to 30 minutes, t1/2 is 2 to 4 minutes幻灯片12
Nitroglycerin 【Pharmacokinetics】 the drug is not administrated by oral route. Because of Significant first-pass effects.幻灯片 9 It is usually given sublingually, may be given either topically or inhalation ally or buccally. 幻灯片 11 If sublingual route, the bioavailability (F) is 80%, the onset of action is 1 to 2 minutes, and the duration of action is 20 to 30 minutes, t1/2 is 2 to 4 minutes. 幻灯片 12
What's meaning of first-pass effect?Concentration of the drug is decreased inblood because it is metabolized by the liverand/or chemical structure is destroyed ingastrointestinal tract.幻灯片8
What’s meaning of first-pass effect? Concentration of the drug is decreased in blood because it is metabolized by the liver and/or chemical structure is destroyed in gastrointestinal tract . 幻灯片 8