1. Aspirin 1.1 Actions and therapeutic uses: B Anti-rheumatic actions: at large dose(4-6 g/d) C Anti-aggregation of platelets and vasoconstriction: at small dose(100 mg/d) irreversibly inhibits thromboxane production in platelets without markedly affecting PGl 2 in the endothelial cells of the blood vessel
1.1 Actions and therapeutic uses: B Anti-rheumatic actions: at large dose (4-6 g/d). C Anti-aggregation of platelets and vasoconstriction: at small dose (~100 mg/d), irreversibly inhibits thromboxane production in platelets without markedly affecting PGI2 in the endothelial cells of the blood vessel. 1. Aspirin
1. Aspirin 1.2 Adverse effects Gastrointestinal effects: epigastric distress, nausea and vomiting, bleeding, ulcer Allergic effects Urticaria(风疹) Bronchoconstriction(aspirin asthma) angioneurotic edema
1.2 Adverse effects: Gastrointestinal effects: epigastric distress, nausea and vomiting, bleeding, ulcer. Allergic effects: Urticaria （风疹） Bronchoconstriction (aspirin asthma) angioneurotic edema 1. Aspirin
1. Aspirin 1.2 Adverse effects: Prolonged bleeding time Excessive ventilation: respiratory alkalosis Salicylism(水杨酸反应): toxicity in the CNS (headache, dizziness, nausea, vomiting, tinnitus) Reye's syndrome: liver and brain injury in children with virus infection
1.2 Adverse effects: Prolonged bleeding time Excessive ventilation: respiratory alkalosis Salicylism (水杨酸反应)：toxicity in the CNS (headache, dizziness, nausea, vomiting, tinnitus) Reye’s syndrome: liver and brain injury in children with virus infection 1. Aspirin
2. Acetaminophen(对乙酰氨基酚) Slow and prolonged antipyretic and analgesic effects a No obvious anti-inflammation effect a Less stimulation to gastrointestinal tract Damage of liver and kidney if used for a long time and at high dose
2. Acetaminophen （对乙酰氨基酚） ◼ Slow and prolonged antipyretic and analgesic effects ◼ No obvious anti-inflammation effect ◼ Less stimulation to gastrointestinal tract ◼ Damage of liver and kidney if used for a long time and at high dose
3. indomethacin(吲哚美辛) One of the most potent inhibitors of COx High potency of anti-inflammatory, analgesic, and antipyretic activity Used for ankylosing spondylitis(强直性脊柱炎SA, Osteoarthritis(骨关节炎OA) and gout(痛风) Effective in treating patent ductus arteriosus(动脉导 管未闭)
3. Indomethacin（吲哚美辛） ◼ One of the most potent inhibitors of COX ◼ High potency of anti-inflammatory, analgesic, and antipyretic activity ◼ Used for ankylosing spondylitis (强直性脊柱炎SA)， Osteoarthritis (骨关节炎OA) and gout (痛风) ◼ Effective in treating patent ductus arteriosus （动脉导 管未闭）