Periplasmic Flagella Diagram AF Axial Fibril os Outer Sheath IP Inser tion pore LL Lipoprotein Layer Nr Nuclear Region AF AF : 下:::: …∴∷ AF NR
6 Periplasmic Flagella Diagram
Cross-Section of Spirochete with Periplasmic Flagella Cross section of Borrelia burgdorferi endoflagella Periplasmic axial fibrils or agella axial filaments Cell wall Outer Cytoplasmic envelope membrane OUter sheath) Page: 301 m前
7 Cross-Section of Spirochete with Periplasmic Flagella endoflagella, axial fibrils or axial filaments. (Outer sheath) Cross section of Borrelia burgdorferi Page: 301
"Spirochaetales Associated Human Diseases Genus Species Disease Treponema pallidum ssp. pallidum Syphilis 3 subspecies) pallidum ssp. endemicum Bejel pallidum ssp. pertenueYaws, framboise T carateum Pinta Borrelia burgdorferi Lyme disease(borreliosis) recurrentis Epidemic relapsing fever Many species Endemic relapsing fever Leptospira interrogans Leptospirosis (Weil's Disease)
8 Genus Species Disease Treponema (3 subspecies) pallidum ssp. pallidum pallidum ssp. endemicum pallidum ssp. pertenue T. carateum Syphilis Bejel Yaws, framboisie Pinta Borrelia burgdorferi recurrentis Many species Lyme disease (borreliosis) Epidemic relapsing fever Endemic relapsing fever Leptospira interrogans Leptospirosis (Weil’s Disease) *Spirochaetales Associated Human Diseases
Treponema pallidum Physiology Strictly human pathogen -slow replication( time of replication =30 hrs Treponema pallidum testis infected rabbit Too thin to be visible in light microscope( darkfield, fluorescence Do not survive well outside of host Not cultivable Darkfield Microscopy of Treponema pallidum
9 Treponema pallidum • Physiology -Strictly human pathogen -Slow replication (time of replication = 30 hrs) -Too thin to be visible in light microscope ( darkfield, fluorescence) -Do not survive well outside of host -Not cultivable Treponema pallidum - testis infected rabbit Darkfield Microscopy of Treponema pallidum
. Syphilis Transmission sexual contact, genital congenital in utero or during birth transfusion of blood Not highly contagious (-30% chance of acquiring disease after single exposure to infected partner), but transmission rate dependent upon stage of disease ong incubation period during which time host is non-infectious Chronic infection slowly progressiⅳve
10 •Syphilis • Transmission - sexual contact, genital - congenital in utero or during birth - transfussion of blood Not highly contagious (~30% chance of acquiring disease after single exposure to infected partner) , but transmission rate dependent upon stage of disease Long incubation period during which time host is non-infectious •Chronic infection slowly progressive