Hepatitis a, C, E Zhigang Yi(易志刚) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University
Hepa%%s'A,'C,'E Zhigang'Yi'（易志刚） MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University
Characteristics of Hepatitis viruses Viru Hepatitis a Hepatitis c Hepatitis e Family Picornaviridae Flaviviridae Hepeviridae Envelope Stability Heat and acid-stable Ether-sensitive Heat-stable acid-sensitive Genome + SsRNA SsrnA + SSRNa Genome size 7.5kb 9.6kb 7.2kb Transmission Fecal-oral Parenteral Chronic disease Nevel Vaccine Y∈ No Yes Oncogenic Yes No
Characteris%cs'of'Hepa%%s'Viruses' Family'''''''''''''''''Picornaviridae''''''''''''''''''''''Flaviviridae'''''''''''''''''''''''''''Hepeviridae'''''''''''''''''''''' Virus''''''''''''''''''''''Hepa%%s'A'''''''''''''''''''''''Hepa%%s'C'''''''''''''''''''''''''''''''''Hepa%%s'E' Envelope''''''''''''''''No'''''''''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''No' Genome'''''''''''''''+'ssRNA''''''''''''''''''''''''''''''''+'ssRNA'''''''''''''''''''''''''''''''''''+'ssRNA''''''''''''''''''''' Genome'size'''''''''''7.5kb''''''''''''''''''''''''''''''''''9.6kb''''''''''''''''''''''''''''''''''''''''''7.2kb''''''''''''''''''''''''''''''''''' Stability''''''''''''''''Heat'and'acidNstable''''''''''EtherNsensi%ve,'''''''''''''''''''HeatNstable''' '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''acidNsensi%ve''''''''' Transmission'''''''''''FecalNoral'''''''''''''''''''''Parenteral'''''''''''''''''''''''''''''''''FecalNoral' Chronic'disease'''''''''Never''''''''''''''''''''''''''''Yes'''''''''''''''''''''''''''''''''''''''''''''''Never' Vaccine''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''No''''''''''''''''''''''''''''''''''''''''''''''''Yes' Oncogenic''''''''''''''''''No''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''''''No
Characteristics of Hepatitis viruses Viru Hepatitis a Hepatitis c Hepatitis e Family Picornaviridae Flaviviridae Hepeviridae Envelope Stability Heat and acid-stable Ether-sensitive Heat-stable acid-sensitive Genome + Ssrna + ssRNA ssRNA Genome size 7.5kb 9.6kb 7.2kb Transmission Fecal-oral Parenteral Chronic disease Nevel Vaccine Y∈ No Yes Oncogenic Yes No
Characteris%cs'of'Hepa%%s'Viruses' Family'''''''''''''''''Picornaviridae''''''''''''''''''''''Flaviviridae'''''''''''''''''''''''''''Hepeviridae'''''''''''''''''''''' Virus''''''''''''''''''''''Hepa%%s'A'''''''''''''''''''''''Hepa%%s'C'''''''''''''''''''''''''''''''''Hepa%%s'E' Envelope''''''''''''''''No'''''''''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''No' Genome'''''''''''''''+'ssRNA''''''''''''''''''''''''''''''''+'ssRNA'''''''''''''''''''''''''''''''''''+'ssRNA''''''''''''''''''''' Genome'size'''''''''''7.5kb''''''''''''''''''''''''''''''''''9.6kb''''''''''''''''''''''''''''''''''''''''''7.2kb''''''''''''''''''''''''''''''''''' Stability''''''''''''''''Heat'and'acidNstable''''''''''EtherNsensi%ve,'''''''''''''''''''HeatNstable''' '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''acidNsensi%ve''''''''' Transmission'''''''''''FecalNoral'''''''''''''''''''''Parenteral'''''''''''''''''''''''''''''''''FecalNoral' Chronic'disease'''''''''Never''''''''''''''''''''''''''''Yes'''''''''''''''''''''''''''''''''''''''''''''''Never' Vaccine''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''No''''''''''''''''''''''''''''''''''''''''''''''''Yes' Oncogenic''''''''''''''''''No''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''''''No
Characteristics of Hepatitis viruses Viru Hepatitis A Hepatitis c Hepatitis e Family Picornaviridae Flaviviridae Hepeviridae Envelope Stability Heat and acid-stableEther-sensitive Heat-stable acid-sensitive Genome + SSRNA + ssrna ssRNA Genome size 7.5kb 9.6kb 7.2kb TransmissionFecal-oral Parenteral Chronic disease Never Yes Nevel Vaccine Yes No Yes Oncogenic Yes No
Characteris%cs'of'Hepa%%s'Viruses' Family'''''''''''''''''Picornaviridae''''''''''''''''''''''Flaviviridae'''''''''''''''''''''''''''Hepeviridae'''''''''''''''''''''' Virus''''''''''''''''''''''Hepa%%s'A'''''''''''''''''''''''Hepa%%s'C'''''''''''''''''''''''''''''''''Hepa%%s'E' Envelope''''''''''''''''No'''''''''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''No' Genome'''''''''''''''+'ssRNA''''''''''''''''''''''''''''''''+'ssRNA'''''''''''''''''''''''''''''''''''+'ssRNA''''''''''''''''''''' Genome'size'''''''''''7.5kb''''''''''''''''''''''''''''''''''9.6kb''''''''''''''''''''''''''''''''''''''''''7.2kb''''''''''''''''''''''''''''''''''' Stability''''''''''''''''Heat'and'acidNstable''''''''''EtherNsensi%ve,'''''''''''''''''''HeatNstable''' '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''acidNsensi%ve''''''''' Transmission'''''''''''FecalNoral'''''''''''''''''''''Parenteral'''''''''''''''''''''''''''''''''FecalNoral' Chronic'disease'''''''''Never''''''''''''''''''''''''''''Yes'''''''''''''''''''''''''''''''''''''''''''''''Never' Vaccine''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''No''''''''''''''''''''''''''''''''''''''''''''''''Yes' Oncogenic''''''''''''''''''No''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''''''No
Characteristics of Hepatitis Viruses Viru Hepatitis A Hepatitis c Hepatitis e Family Picornaviridae Flaviviridae Hepeviridae Envelope No Stability Heat and acid-stable Ether-sensitive Heat-stable acid-sensitive Genome + SSRNA + ssrna ssRNA Genome size 7.5kb 9.6kb 7.2kb Transmission Fecal-oral Parenteral Chronic disease Never Yes Nevel Vaccine Yes No Yes Oncogenic Yes No
Characteris%cs'of'Hepa%%s'Viruses' Family'''''''''''''''''Picornaviridae''''''''''''''''''''''Flaviviridae'''''''''''''''''''''''''''Hepeviridae'''''''''''''''''''''' Virus''''''''''''''''''''''Hepa%%s'A'''''''''''''''''''''''Hepa%%s'C'''''''''''''''''''''''''''''''''Hepa%%s'E' Envelope''''''''''''''''No'''''''''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''No' Genome'''''''''''''''+'ssRNA''''''''''''''''''''''''''''''''+'ssRNA'''''''''''''''''''''''''''''''''''+'ssRNA''''''''''''''''''''' Genome'size'''''''''''7.5kb''''''''''''''''''''''''''''''''''9.6kb''''''''''''''''''''''''''''''''''''''''''7.2kb''''''''''''''''''''''''''''''''''' Stability''''''''''''''''Heat'and'acidNstable''''''''''EtherNsensi%ve,'''''''''''''''''''HeatNstable''' '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''acidNsensi%ve''''''''' Transmission'''''''''''FecalNoral'''''''''''''''''''''Parenteral'''''''''''''''''''''''''''''''''FecalNoral' Chronic'disease'''''''''Never''''''''''''''''''''''''''''Yes'''''''''''''''''''''''''''''''''''''''''''''''Never' Vaccine''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''No''''''''''''''''''''''''''''''''''''''''''''''''Yes' Oncogenic''''''''''''''''''No''''''''''''''''''''''''''''''''''Yes''''''''''''''''''''''''''''''''''''''''''''''''No