In the 1990s,with the global genome project, particularly the Human Genome Project (HGP),gene research has been near"the peak',human knowledge on the life world reached an unprecedented depth and breadth. 20世纪90年代，随着全球基因组计划，尤其是人类 隆。 基因研究接近 类对生命世界 的理性认识途到了箭所耒宥的深度写产度。 2025/5/15 6
2025/5/15 6 ★ In the 1990s, with the global genome project, particularly the Human Genome Project (HGP) , gene research has been near “the peak”, human knowledge on the life world reached an unprecedented depth and breadth. 20世纪90年代,随着全球基因组计划，尤其是人类 基因组计划(HGP)规模空前、速度惊人的推进， 基因研究已接近“登峰造极”，人类对生命世界 的理性认识达到了前所未有的深度与广度
In the 20th century,three science and technology projects of human 20世纪的人类三大科技工程 The three major scientific discoveries in the 20th century (The Theory of Relativity,Quantum Theory,DNA Double Delix Structure)have led to three major science and technology projects of human:20世纪三 大科学发现（相对论，量学论，DNA双螺旋结构）导致了人 类三大科技工程： Manhattan Project(nuclear weapons,nuclear power and nuclear technologies)曼哈顿工程（核武器，以及接着而 来的核动力和核技术的广泛应用)： Project Apollo(lunar landing,space research and development));阿波罗工程（登月，航天与空间研究开发）； ★Human Genome Project(HGP)人类基因组工程。 2025/5/15
2025/5/15 7 The three major scientific discoveries in the 20th century (The Theory of Relativity, Quantum Theory, DNA Double Delix Structure) have led to three major science and technology projects of human : 20世纪三 大科学发现(相对论，量子论，DNA双螺旋结构)导致了人 类三大科技工程: ★ Manhattan Project (nuclear weapons, nuclear power and nuclear technologies) 曼哈顿工程(核武器，以及接着而 来的核动力和核技术的广泛应用)； ★ Project Apollo (lunar landing, space research and development);阿波罗工程(登月，航天与空间研究开发); ★ Human Genome Project (HGP) 人类基因组工程。 In the 20th century, three science and technology projects of human 20世纪的人类三大科技工程
Topic 1 Genome and Genomics (基因组和基因组学) 2025/5/15 8
2025/5/15 8 Topic 1 Genome and Genomics (基因组和基因组学)
1.1 Genome: The word 'genome'is from 'gene'and 'chromosome',refers to a full set of chromosomes or genes in an organism. 基因组一词是从genes和chromosomes合成 而来，用来描述生物的全部基因和染色体组成 的概念。 2025/5/15 9
2025/5/15 9 1.1 Genome: The word ‘genome’ is from ‘gene’ and ‘chromosome’ , refers to a full set of chromosomes or genes in an organism. 基因组一词是从 genes 和 chromosomes 合成 而来，用来描述生物的全部基因和染色体组成 的概念
*In 1986,American scientist Thomas Roderick first proposed the concept of genomics. Genomics is the study of an organism's entire genome,including genome mapping (such as the genetic map,physical map and transcription map),nucleotide sequence analysis,gene mapping and gene functional analysis. 1986年，美国科学家Thomas Roderick首先提出 了基因组学(genomics)的概念。指对所有基因 进行基因组作图（包括遗传图谱，物理图谱和转 录图谱)，核苷酸序列分析，基因定位和基因功 能分析。 2025/5/15 10
2025/5/15 10 ★In 1986, American scientist Thomas Roderick first proposed the concept of genomics. Genomics is the study of an organism's entire genome, including genome mapping (such as the genetic map, physical map and transcription map), nucleotide sequence analysis, gene mapping and gene functional analysis. 1986年, 美国科学家 Thomas Roderick 首先提出 了基因组学 (genomics) 的概念。指对所有基因 进行基因组作图（包括遗传图谱，物理图谱和转 录图谱），核苷酸序列分析，基因定位和基因功 能分析